Oxidative and nitrosative stress defences of Helicobacter and Campylobacter species that counteract mammalian immunity

Annika Flint, Alain Stintzi, Lígia M. Saraiva

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)

Abstract

Helicobacter and Campylobacter species are Gram-negative microaerophilic host-associated heterotrophic bacteria that invade the digestive tract of humans and animals. Campylobacter jejuni is the major worldwide cause of foodborne gastroenteritis in humans, while Helicobacter pylori is ubiquitous in over half of the world's population causing gastric and duodenal ulcers. The colonisation of the gastrointestinal system by Helicobacter and Campylobacter relies on numerous cellular defences to sense the host environment and respond to adverse conditions, including those imposed by the host immunity. An important antimicrobial tool of the mammalian innate immune system is the generation of harmful oxidative and nitrosative stresses to which pathogens are exposed during phagocytosis. This review summarises the regulators, detoxifying enzymes and subversion mechanisms of Helicobacter and Campylobacter that ultimately promote the successful infection of humans.

Original languageEnglish
Pages (from-to)938-960
Number of pages23
JournalFems Microbiology Reviews
Volume40
Issue number6
DOIs
Publication statusPublished - 1 Nov 2016

Keywords

  • Bacterial defences
  • Campylobacter
  • Helicobacter
  • Innate immunity
  • Pathogen

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