Outer Retina and Choroidal Thickness in Intermediate Age-Related Macular Degeneration

Reticular Pseudodrusen Findings

Pedro Camacho, Marco Dutra-Medeiros, Diogo Cabral, Rufino Silva

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: To evaluate outer retina and choroidal thickness in subjects with intermediate age-related macular degeneration (iAMD) and to describe associations with the presence of reticular pseudodrusen (RPD). Methods: This was a retrospective, cross-sectional analysis of 157 consecutive eyes (specifically: 62 eyes classified as having RPD and 95 eyes with drusen ≥125 μm). Only cases with digital color fundus photographs, red-free, and infrared, obtained and graded according to the Age-Related Eye Disease Study to define iAMD, were used for this study. Outer retina and choroidal thickness were manually segmented and quantified at 12 locations in the horizontal meridian. Results: RPD appeared to be associated with thinning of the outer layers even after adjustment for gender and age. The presence of RPD in iAMD decreased with increase of choroidal thickness (total odds ratio [OR] 0.991, 95% confidence interval [CI] 0.985-0.996; nasal OR 0.992, 95% CI 0.986-0.997), with increased thickness of the myoid zone of the photoreceptors (total OR 0.812, 95% CI 0.688-0.958; nasal OR 0.863, 95% CI 0.755-0.987) and with increased thickness of the outer segment of the photoreceptors (total OR 0.850, 95% CI 0.731-0.989; nasal OR 0.857, 95% CI 0.736-0.989). Conclusions: The greatest differences between eyes with and without RPD are found at the level of the choroidal thickness and at the level of the photoreceptors.

Original languageEnglish
Pages (from-to)212-220
Number of pages9
JournalOphthalmic research
Volume59
Issue number4
DOIs
Publication statusPublished - 1 May 2018

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Macular Degeneration
Retina
Odds Ratio
Confidence Intervals
Nose
Meridians
Eye Diseases
Color
Cross-Sectional Studies

Cite this

@article{f475b0d6dcba4dd9ad6d2cd7144ea63b,
title = "Outer Retina and Choroidal Thickness in Intermediate Age-Related Macular Degeneration: Reticular Pseudodrusen Findings",
abstract = "Purpose: To evaluate outer retina and choroidal thickness in subjects with intermediate age-related macular degeneration (iAMD) and to describe associations with the presence of reticular pseudodrusen (RPD). Methods: This was a retrospective, cross-sectional analysis of 157 consecutive eyes (specifically: 62 eyes classified as having RPD and 95 eyes with drusen ≥125 μm). Only cases with digital color fundus photographs, red-free, and infrared, obtained and graded according to the Age-Related Eye Disease Study to define iAMD, were used for this study. Outer retina and choroidal thickness were manually segmented and quantified at 12 locations in the horizontal meridian. Results: RPD appeared to be associated with thinning of the outer layers even after adjustment for gender and age. The presence of RPD in iAMD decreased with increase of choroidal thickness (total odds ratio [OR] 0.991, 95{\%} confidence interval [CI] 0.985-0.996; nasal OR 0.992, 95{\%} CI 0.986-0.997), with increased thickness of the myoid zone of the photoreceptors (total OR 0.812, 95{\%} CI 0.688-0.958; nasal OR 0.863, 95{\%} CI 0.755-0.987) and with increased thickness of the outer segment of the photoreceptors (total OR 0.850, 95{\%} CI 0.731-0.989; nasal OR 0.857, 95{\%} CI 0.736-0.989). Conclusions: The greatest differences between eyes with and without RPD are found at the level of the choroidal thickness and at the level of the photoreceptors.",
author = "Pedro Camacho and Marco Dutra-Medeiros and Diogo Cabral and Rufino Silva",
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Outer Retina and Choroidal Thickness in Intermediate Age-Related Macular Degeneration : Reticular Pseudodrusen Findings. / Camacho, Pedro; Dutra-Medeiros, Marco; Cabral, Diogo; Silva, Rufino.

In: Ophthalmic research, Vol. 59, No. 4, 01.05.2018, p. 212-220.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Outer Retina and Choroidal Thickness in Intermediate Age-Related Macular Degeneration

T2 - Reticular Pseudodrusen Findings

AU - Camacho, Pedro

AU - Dutra-Medeiros, Marco

AU - Cabral, Diogo

AU - Silva, Rufino

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Purpose: To evaluate outer retina and choroidal thickness in subjects with intermediate age-related macular degeneration (iAMD) and to describe associations with the presence of reticular pseudodrusen (RPD). Methods: This was a retrospective, cross-sectional analysis of 157 consecutive eyes (specifically: 62 eyes classified as having RPD and 95 eyes with drusen ≥125 μm). Only cases with digital color fundus photographs, red-free, and infrared, obtained and graded according to the Age-Related Eye Disease Study to define iAMD, were used for this study. Outer retina and choroidal thickness were manually segmented and quantified at 12 locations in the horizontal meridian. Results: RPD appeared to be associated with thinning of the outer layers even after adjustment for gender and age. The presence of RPD in iAMD decreased with increase of choroidal thickness (total odds ratio [OR] 0.991, 95% confidence interval [CI] 0.985-0.996; nasal OR 0.992, 95% CI 0.986-0.997), with increased thickness of the myoid zone of the photoreceptors (total OR 0.812, 95% CI 0.688-0.958; nasal OR 0.863, 95% CI 0.755-0.987) and with increased thickness of the outer segment of the photoreceptors (total OR 0.850, 95% CI 0.731-0.989; nasal OR 0.857, 95% CI 0.736-0.989). Conclusions: The greatest differences between eyes with and without RPD are found at the level of the choroidal thickness and at the level of the photoreceptors.

AB - Purpose: To evaluate outer retina and choroidal thickness in subjects with intermediate age-related macular degeneration (iAMD) and to describe associations with the presence of reticular pseudodrusen (RPD). Methods: This was a retrospective, cross-sectional analysis of 157 consecutive eyes (specifically: 62 eyes classified as having RPD and 95 eyes with drusen ≥125 μm). Only cases with digital color fundus photographs, red-free, and infrared, obtained and graded according to the Age-Related Eye Disease Study to define iAMD, were used for this study. Outer retina and choroidal thickness were manually segmented and quantified at 12 locations in the horizontal meridian. Results: RPD appeared to be associated with thinning of the outer layers even after adjustment for gender and age. The presence of RPD in iAMD decreased with increase of choroidal thickness (total odds ratio [OR] 0.991, 95% confidence interval [CI] 0.985-0.996; nasal OR 0.992, 95% CI 0.986-0.997), with increased thickness of the myoid zone of the photoreceptors (total OR 0.812, 95% CI 0.688-0.958; nasal OR 0.863, 95% CI 0.755-0.987) and with increased thickness of the outer segment of the photoreceptors (total OR 0.850, 95% CI 0.731-0.989; nasal OR 0.857, 95% CI 0.736-0.989). Conclusions: The greatest differences between eyes with and without RPD are found at the level of the choroidal thickness and at the level of the photoreceptors.

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U2 - 10.1159/000484349

DO - 10.1159/000484349

M3 - Article

VL - 59

SP - 212

EP - 220

JO - Ophthalmic research

JF - Ophthalmic research

SN - 0030-3747

IS - 4

ER -