Organocatalyzed Asymmetric Michael Reaction in Ionic Liquids-Carbon Dioxide

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Abstract

The asymmetric Michael reaction catalysed by the chiral amines quinine, quinidine, L-proline, (-)-sparteine, (-)ephedrine and the quinidine derivative QD4 was studied in ionic liquids and by dissolving CO(2) using ethyl 2-cyclopentanone carboxylate and methyl vinyl ketone as model substrates. While the observed yields in the ionic liquids based on the methylimidazolium cation were similar to the ones obtained in toluene, the enantioselectivities were considerably lower, However, the dissolution of CO(2) in the ionic liquid provokes a considerable increase on the enantioselectivities.
Original languageUnknown
Pages (from-to)235-245
JournalIonic Liquids in Organic Synthesis
Volume950
Issue numberNA
DOIs
Publication statusPublished - 1 Jan 2007

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