Optimization of an Arterialized Venous Fasciocutaneous Flap in the Abdomen of the Rat

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Abstract

Background: Although numerous experimental models of arterialized venous flaps (AVFs) have been proposed, no single model has gained widespread acceptance. The main aim of this work was to evaluate the survival area of AVFs produced with different vascular constructs in the abdomen of the rat. Methods: Fifty-Three male rats were divided into 4 groups. In group I (n = 12), a 5-cm-long and 3-cm-wide conventional epigastric flap was raised on the left side of the abdomen. This flap was pedicled on the superficial caudal epigastric vessels caudally and on the lateral thoracic vein cranially. In groups II, III, and IV, a similar flap was raised, but the superficial epigastric artery was ligated. In these groups, AVFs were created using the following arterial venous anastomosis at the caudal end of the flap: group II (n = 13) a 1-mm-long side-To-side anastomosis was performed between the femoral artery and vein laterally to the ending of the superficial caudal epigastric vein. In group III (n = 14), in addition to the procedure described for group II, the femoral vein was ligated medially. Finally, in group IV (n = 14), the superficial caudal epigastric vein was cut from the femoral vein with a 1-mm-long ellipse of adjacent tissue, and an end-To-side arterial venous anastomosis was established between it and the femoral artery. Results: Seven days postoperatively, the percentage of flap survival was 98.89 ± 1.69, 68.84 ± 7.36, 63.84 ± 10.38, 76.86 ± 13.67 in groups I-IV, respectively. Conclusion: An optimized AVF can be produced using the vascular architecture described for group IV.

Original languageEnglish
Article numbere1436
Pages (from-to)Online
Number of pages8
JournalPlastic and Reconstructive Surgery - Global Open
Volume5
Issue number8
DOIs
Publication statusPublished - Aug 2017

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Femoral Vein
Abdomen
Veins
Femoral Artery
Blood Vessels
Epigastric Arteries
Surgical Flaps
Theoretical Models
Thorax

Cite this

@article{960b8f2d7f65484ca279b0c5cfb9f71e,
title = "Optimization of an Arterialized Venous Fasciocutaneous Flap in the Abdomen of the Rat",
abstract = "Background: Although numerous experimental models of arterialized venous flaps (AVFs) have been proposed, no single model has gained widespread acceptance. The main aim of this work was to evaluate the survival area of AVFs produced with different vascular constructs in the abdomen of the rat. Methods: Fifty-Three male rats were divided into 4 groups. In group I (n = 12), a 5-cm-long and 3-cm-wide conventional epigastric flap was raised on the left side of the abdomen. This flap was pedicled on the superficial caudal epigastric vessels caudally and on the lateral thoracic vein cranially. In groups II, III, and IV, a similar flap was raised, but the superficial epigastric artery was ligated. In these groups, AVFs were created using the following arterial venous anastomosis at the caudal end of the flap: group II (n = 13) a 1-mm-long side-To-side anastomosis was performed between the femoral artery and vein laterally to the ending of the superficial caudal epigastric vein. In group III (n = 14), in addition to the procedure described for group II, the femoral vein was ligated medially. Finally, in group IV (n = 14), the superficial caudal epigastric vein was cut from the femoral vein with a 1-mm-long ellipse of adjacent tissue, and an end-To-side arterial venous anastomosis was established between it and the femoral artery. Results: Seven days postoperatively, the percentage of flap survival was 98.89 ± 1.69, 68.84 ± 7.36, 63.84 ± 10.38, 76.86 ± 13.67 in groups I-IV, respectively. Conclusion: An optimized AVF can be produced using the vascular architecture described for group IV.",
author = "Diogo Casal and Eduarda Mota-Silva and Diogo Pais and In{\^e}s Iria and Videira, {Paula A.} and David Tanganho and Sara Alves and Lu{\'i}s Mascarenhas-Lemos and {Martins Ferreira}, Jos{\'e} and M{\'a}rio Ferraz-Oliveira and Valentina Vassilenko and O'Neill, {Jo{\~a}o Goyri}",
year = "2017",
month = "8",
doi = "10.1097/GOX.0000000000001436",
language = "English",
volume = "5",
pages = "Online",
journal = "Plastic and reconstructive surgery. Global open",
issn = "2169-7574",
publisher = "Lippincott, Williams & Wilkins",
number = "8",

}

TY - JOUR

T1 - Optimization of an Arterialized Venous Fasciocutaneous Flap in the Abdomen of the Rat

AU - Casal, Diogo

AU - Mota-Silva, Eduarda

AU - Pais, Diogo

AU - Iria, Inês

AU - Videira, Paula A.

AU - Tanganho, David

AU - Alves, Sara

AU - Mascarenhas-Lemos, Luís

AU - Martins Ferreira, José

AU - Ferraz-Oliveira, Mário

AU - Vassilenko, Valentina

AU - O'Neill, João Goyri

PY - 2017/8

Y1 - 2017/8

N2 - Background: Although numerous experimental models of arterialized venous flaps (AVFs) have been proposed, no single model has gained widespread acceptance. The main aim of this work was to evaluate the survival area of AVFs produced with different vascular constructs in the abdomen of the rat. Methods: Fifty-Three male rats were divided into 4 groups. In group I (n = 12), a 5-cm-long and 3-cm-wide conventional epigastric flap was raised on the left side of the abdomen. This flap was pedicled on the superficial caudal epigastric vessels caudally and on the lateral thoracic vein cranially. In groups II, III, and IV, a similar flap was raised, but the superficial epigastric artery was ligated. In these groups, AVFs were created using the following arterial venous anastomosis at the caudal end of the flap: group II (n = 13) a 1-mm-long side-To-side anastomosis was performed between the femoral artery and vein laterally to the ending of the superficial caudal epigastric vein. In group III (n = 14), in addition to the procedure described for group II, the femoral vein was ligated medially. Finally, in group IV (n = 14), the superficial caudal epigastric vein was cut from the femoral vein with a 1-mm-long ellipse of adjacent tissue, and an end-To-side arterial venous anastomosis was established between it and the femoral artery. Results: Seven days postoperatively, the percentage of flap survival was 98.89 ± 1.69, 68.84 ± 7.36, 63.84 ± 10.38, 76.86 ± 13.67 in groups I-IV, respectively. Conclusion: An optimized AVF can be produced using the vascular architecture described for group IV.

AB - Background: Although numerous experimental models of arterialized venous flaps (AVFs) have been proposed, no single model has gained widespread acceptance. The main aim of this work was to evaluate the survival area of AVFs produced with different vascular constructs in the abdomen of the rat. Methods: Fifty-Three male rats were divided into 4 groups. In group I (n = 12), a 5-cm-long and 3-cm-wide conventional epigastric flap was raised on the left side of the abdomen. This flap was pedicled on the superficial caudal epigastric vessels caudally and on the lateral thoracic vein cranially. In groups II, III, and IV, a similar flap was raised, but the superficial epigastric artery was ligated. In these groups, AVFs were created using the following arterial venous anastomosis at the caudal end of the flap: group II (n = 13) a 1-mm-long side-To-side anastomosis was performed between the femoral artery and vein laterally to the ending of the superficial caudal epigastric vein. In group III (n = 14), in addition to the procedure described for group II, the femoral vein was ligated medially. Finally, in group IV (n = 14), the superficial caudal epigastric vein was cut from the femoral vein with a 1-mm-long ellipse of adjacent tissue, and an end-To-side arterial venous anastomosis was established between it and the femoral artery. Results: Seven days postoperatively, the percentage of flap survival was 98.89 ± 1.69, 68.84 ± 7.36, 63.84 ± 10.38, 76.86 ± 13.67 in groups I-IV, respectively. Conclusion: An optimized AVF can be produced using the vascular architecture described for group IV.

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U2 - 10.1097/GOX.0000000000001436

DO - 10.1097/GOX.0000000000001436

M3 - Article

VL - 5

SP - Online

JO - Plastic and reconstructive surgery. Global open

JF - Plastic and reconstructive surgery. Global open

SN - 2169-7574

IS - 8

M1 - e1436

ER -