Optimal design and experimental validation of synchronous, asynchronous and flow-modulated, simulated moving-bed processes using a single-column setup

Rui C R Rodrigues; João M. M.  Araújo; José Paulo Barbosa Mota

doi:10.1016/j.chroma.2007.01.103

Optimal design and experimental validation of synchronous, asynchronous and flow-modulated, simulated moving-bed processes using a single-column setup

Rui C R Rodrigues, João M. M. Araújo, José Paulo Barbosa Mota

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

The performance of asynchronous (Varicol) and flow-modulated (PowerFeed) simulated moving-bed processes, as well as their combination into a single hybrid scheme, are studied both experimentally and by numerical simulation. A recently developed single-column experimental setup is employed to demonstrate the feasibility of the various schemes, explore the effect of their major operating parameters, and illustrate the performance enhancements that are obtained when these schemes are properly optimized. The experimental feasibility and effectiveness of the various schemes are assessed by running and comparing optimized configurations for the linear separation of two nucleosides on a high-performance reversed-phase stationary phase. (c) 2007 Elsevier B.V. All rights reserved.

Original language	Unknown
Pages (from-to)	14-23
Journal	Journal Of Chromatography A
Volume	1162
Issue number	1
DOIs	https://doi.org/10.1016/j.chroma.2007.01.103
Publication status	Published - 1 Jan 2007

Access to Document

10.1016/j.chroma.2007.01.103

Cite this

@article{445d380de0e249a88c615d58a57e3be9,

title = "Optimal design and experimental validation of synchronous, asynchronous and flow-modulated, simulated moving-bed processes using a single-column setup",

abstract = "The performance of asynchronous (Varicol) and flow-modulated (PowerFeed) simulated moving-bed processes, as well as their combination into a single hybrid scheme, are studied both experimentally and by numerical simulation. A recently developed single-column experimental setup is employed to demonstrate the feasibility of the various schemes, explore the effect of their major operating parameters, and illustrate the performance enhancements that are obtained when these schemes are properly optimized. The experimental feasibility and effectiveness of the various schemes are assessed by running and comparing optimized configurations for the linear separation of two nucleosides on a high-performance reversed-phase stationary phase. (c) 2007 Elsevier B.V. All rights reserved.",

author = "Rodrigues, {Rui C R} and Ara{\'u}jo, {Jo{\~a}o M. M.} and Mota, {Jos{\'e} Paulo Barbosa}",

year = "2007",

month = jan,

day = "1",

doi = "10.1016/j.chroma.2007.01.103",

language = "Unknown",

volume = "1162",

pages = "14--23",

journal = "Journal Of Chromatography A",

issn = "0021-9673",

publisher = "Elsevier Science B.V., Amsterdam.",

number = "1",

}

TY - JOUR

T1 - Optimal design and experimental validation of synchronous, asynchronous and flow-modulated, simulated moving-bed processes using a single-column setup

AU - Rodrigues, Rui C R

AU - Araújo, João M. M.

AU - Mota, José Paulo Barbosa

PY - 2007/1/1

Y1 - 2007/1/1

N2 - The performance of asynchronous (Varicol) and flow-modulated (PowerFeed) simulated moving-bed processes, as well as their combination into a single hybrid scheme, are studied both experimentally and by numerical simulation. A recently developed single-column experimental setup is employed to demonstrate the feasibility of the various schemes, explore the effect of their major operating parameters, and illustrate the performance enhancements that are obtained when these schemes are properly optimized. The experimental feasibility and effectiveness of the various schemes are assessed by running and comparing optimized configurations for the linear separation of two nucleosides on a high-performance reversed-phase stationary phase. (c) 2007 Elsevier B.V. All rights reserved.

AB - The performance of asynchronous (Varicol) and flow-modulated (PowerFeed) simulated moving-bed processes, as well as their combination into a single hybrid scheme, are studied both experimentally and by numerical simulation. A recently developed single-column experimental setup is employed to demonstrate the feasibility of the various schemes, explore the effect of their major operating parameters, and illustrate the performance enhancements that are obtained when these schemes are properly optimized. The experimental feasibility and effectiveness of the various schemes are assessed by running and comparing optimized configurations for the linear separation of two nucleosides on a high-performance reversed-phase stationary phase. (c) 2007 Elsevier B.V. All rights reserved.

U2 - 10.1016/j.chroma.2007.01.103

DO - 10.1016/j.chroma.2007.01.103

M3 - Article

SN - 0021-9673

VL - 1162

SP - 14

EP - 23

JO - Journal Of Chromatography A

JF - Journal Of Chromatography A

IS - 1

ER -