One-year survey of paediatric anaphylaxis in an allergy department

A Gaspar, Claudia N. Santos, Moisés S. Piedade, C Santa-Marta, G Pires, Graça Sampaio, Cristina Arêde, L M Borrego, Mário Morais-Almeida

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

AIM: To determine the frequency of anaphylaxis in an allergy outpatient department, allowing a better understanding regarding aetiology, clinical manifestations and management, in children and adolescents.

METHODS: From among 3646 patients up to 18 years old observed during one-year period, we included those with history of anaphylaxis reported by allergists.

RESULTS: Sixty-four children had history of anaphylaxis (prevalence of 1.8%), with mean age 8.1±5.5 years, 61% being male. Median age of the first anaphylactic episode was 3 years (1 month-17 years). The majority of patients had food-induced anaphylaxis (84%): milk 22, egg 7, peanut 6, tree nuts 6, fresh fruits 6, crustaceans 4, fish 4 and wheat 2. Food-associated exercise-induced anaphylaxis was reported in 2 adolescents. Drug-induced anaphylaxis occurred in 8%: 4 non-steroidal anti-inflammatory drugs and 1 amoxicillin. Three children had cold-induced anaphylaxis, one adolescent had anaphylaxis to latex and one child had anaphylaxis to insect sting. The majority (73%) had no previous diagnosis of the etiologic factor. Symptoms reported were mainly mucocutaneous (94%) and respiratory (84%), followed by gastrointestinal (42%) and cardiovascular (25%). Fifty-one patients were admitted to the emergency department, although only 33% were treated with epinephrine. Recurrence of anaphylaxis occurred in 26 patients (3 or more episodes in 14).

CONCLUSIONS: In our paediatric population, the main triggering agent of anaphylaxis was IgE-mediated food allergy. Epinephrine is underused, as reported by others. Often, children have several episodes before being assessed by an allergist. We stress the importance of systematic notification and improvement of educational programmes in order to achieve a better preventive and therapeutic management of this life-threatening entity.

Original languageEnglish
Pages (from-to)197-205
Number of pages9
JournalEuropean annals of allergy and clinical immunology
Volume47
Issue number6
Publication statusPublished - Nov 2015

Fingerprint

Anaphylaxis
Hypersensitivity
Pediatrics
Epinephrine
Surveys and Questionnaires
Insect Bites and Stings
Food
Nuts
Food Hypersensitivity
Amoxicillin
Latex
Pharmaceutical Preparations
Immunoglobulin E
Triticum
Ovum
Hospital Emergency Service
Fruit
Fishes
Milk
Anti-Inflammatory Agents

Keywords

  • Adolescent
  • Allergy and Immunology
  • Anaphylaxis
  • Anti-Allergic Agents
  • Child
  • Child, Preschool
  • Drug Hypersensitivity
  • Epinephrine
  • Female
  • Food Hypersensitivity
  • Health Care Surveys
  • Hospital Departments
  • Humans
  • Male
  • Pediatrics
  • Portugal
  • Practice Patterns, Physicians'
  • Predictive Value of Tests
  • Prevalence
  • Recurrence
  • Referral and Consultation
  • Risk Factors
  • Time Factors
  • Treatment Outcome
  • Journal Article

Cite this

Gaspar, A., Santos, C. N., Piedade, M. S., Santa-Marta, C., Pires, G., Sampaio, G., ... Morais-Almeida, M. (2015). One-year survey of paediatric anaphylaxis in an allergy department. European annals of allergy and clinical immunology, 47(6), 197-205.
Gaspar, A ; Santos, Claudia N. ; Piedade, Moisés S. ; Santa-Marta, C ; Pires, G ; Sampaio, Graça ; Arêde, Cristina ; Borrego, L M ; Morais-Almeida, Mário. / One-year survey of paediatric anaphylaxis in an allergy department. In: European annals of allergy and clinical immunology. 2015 ; Vol. 47, No. 6. pp. 197-205.
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Gaspar, A, Santos, CN, Piedade, MS, Santa-Marta, C, Pires, G, Sampaio, G, Arêde, C, Borrego, LM & Morais-Almeida, M 2015, 'One-year survey of paediatric anaphylaxis in an allergy department', European annals of allergy and clinical immunology, vol. 47, no. 6, pp. 197-205.

One-year survey of paediatric anaphylaxis in an allergy department. / Gaspar, A; Santos, Claudia N.; Piedade, Moisés S.; Santa-Marta, C; Pires, G; Sampaio, Graça; Arêde, Cristina; Borrego, L M; Morais-Almeida, Mário.

In: European annals of allergy and clinical immunology, Vol. 47, No. 6, 11.2015, p. 197-205.

Research output: Contribution to journalArticle

TY - JOUR

T1 - One-year survey of paediatric anaphylaxis in an allergy department

AU - Gaspar, A

AU - Santos, Claudia N.

AU - Piedade, Moisés S.

AU - Santa-Marta, C

AU - Pires, G

AU - Sampaio, Graça

AU - Arêde, Cristina

AU - Borrego, L M

AU - Morais-Almeida, Mário

PY - 2015/11

Y1 - 2015/11

N2 - AIM: To determine the frequency of anaphylaxis in an allergy outpatient department, allowing a better understanding regarding aetiology, clinical manifestations and management, in children and adolescents.METHODS: From among 3646 patients up to 18 years old observed during one-year period, we included those with history of anaphylaxis reported by allergists.RESULTS: Sixty-four children had history of anaphylaxis (prevalence of 1.8%), with mean age 8.1±5.5 years, 61% being male. Median age of the first anaphylactic episode was 3 years (1 month-17 years). The majority of patients had food-induced anaphylaxis (84%): milk 22, egg 7, peanut 6, tree nuts 6, fresh fruits 6, crustaceans 4, fish 4 and wheat 2. Food-associated exercise-induced anaphylaxis was reported in 2 adolescents. Drug-induced anaphylaxis occurred in 8%: 4 non-steroidal anti-inflammatory drugs and 1 amoxicillin. Three children had cold-induced anaphylaxis, one adolescent had anaphylaxis to latex and one child had anaphylaxis to insect sting. The majority (73%) had no previous diagnosis of the etiologic factor. Symptoms reported were mainly mucocutaneous (94%) and respiratory (84%), followed by gastrointestinal (42%) and cardiovascular (25%). Fifty-one patients were admitted to the emergency department, although only 33% were treated with epinephrine. Recurrence of anaphylaxis occurred in 26 patients (3 or more episodes in 14).CONCLUSIONS: In our paediatric population, the main triggering agent of anaphylaxis was IgE-mediated food allergy. Epinephrine is underused, as reported by others. Often, children have several episodes before being assessed by an allergist. We stress the importance of systematic notification and improvement of educational programmes in order to achieve a better preventive and therapeutic management of this life-threatening entity.

AB - AIM: To determine the frequency of anaphylaxis in an allergy outpatient department, allowing a better understanding regarding aetiology, clinical manifestations and management, in children and adolescents.METHODS: From among 3646 patients up to 18 years old observed during one-year period, we included those with history of anaphylaxis reported by allergists.RESULTS: Sixty-four children had history of anaphylaxis (prevalence of 1.8%), with mean age 8.1±5.5 years, 61% being male. Median age of the first anaphylactic episode was 3 years (1 month-17 years). The majority of patients had food-induced anaphylaxis (84%): milk 22, egg 7, peanut 6, tree nuts 6, fresh fruits 6, crustaceans 4, fish 4 and wheat 2. Food-associated exercise-induced anaphylaxis was reported in 2 adolescents. Drug-induced anaphylaxis occurred in 8%: 4 non-steroidal anti-inflammatory drugs and 1 amoxicillin. Three children had cold-induced anaphylaxis, one adolescent had anaphylaxis to latex and one child had anaphylaxis to insect sting. The majority (73%) had no previous diagnosis of the etiologic factor. Symptoms reported were mainly mucocutaneous (94%) and respiratory (84%), followed by gastrointestinal (42%) and cardiovascular (25%). Fifty-one patients were admitted to the emergency department, although only 33% were treated with epinephrine. Recurrence of anaphylaxis occurred in 26 patients (3 or more episodes in 14).CONCLUSIONS: In our paediatric population, the main triggering agent of anaphylaxis was IgE-mediated food allergy. Epinephrine is underused, as reported by others. Often, children have several episodes before being assessed by an allergist. We stress the importance of systematic notification and improvement of educational programmes in order to achieve a better preventive and therapeutic management of this life-threatening entity.

KW - Adolescent

KW - Allergy and Immunology

KW - Anaphylaxis

KW - Anti-Allergic Agents

KW - Child

KW - Child, Preschool

KW - Drug Hypersensitivity

KW - Epinephrine

KW - Female

KW - Food Hypersensitivity

KW - Health Care Surveys

KW - Hospital Departments

KW - Humans

KW - Male

KW - Pediatrics

KW - Portugal

KW - Practice Patterns, Physicians'

KW - Predictive Value of Tests

KW - Prevalence

KW - Recurrence

KW - Referral and Consultation

KW - Risk Factors

KW - Time Factors

KW - Treatment Outcome

KW - Journal Article

M3 - Article

VL - 47

SP - 197

EP - 205

JO - European annals of allergy and clinical immunology

JF - European annals of allergy and clinical immunology

SN - 1764-1489

IS - 6

ER -

Gaspar A, Santos CN, Piedade MS, Santa-Marta C, Pires G, Sampaio G et al. One-year survey of paediatric anaphylaxis in an allergy department. European annals of allergy and clinical immunology. 2015 Nov;47(6):197-205.