One-Pot Intercalation Strategy for the Encapsulation of a CO-Releasing Organometallic Molecule in a Layered Double Hydroxide

Isabel B. Calhau, Ana C. Gomes, Sofia M. Bruno, Ana C. Coelho, Clara I.R. Magalhães, Carlos C. Romão, Anabela A. Valente, Isabel S. Gonçalves, Martyn Pillinger

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The photoactivatable CO-releasing molecule (photoCORM) [Mo(CO)3(CNCH2COOH)3] (ALF795) has been incorporated into a Zn,Al layered double hydroxide (LDH) host by a coprecipitation synthesis strategy. Powder X-ray diffraction (PXRD) of the resultant material Zn,Al-ALF795 showed that the ALF795 guest molecules assembled into a monolayer to give a basal spacing of 16.0 Å. FTIR and 13C{1H} CP MAS NMR spectroscopy confirmed that the molecular structure of the tricarbonyl complex was retained upon intercalation. Scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS) and elemental analyses confirmed the phase-purity of Zn,Al-ALF795. The myoglobin assay was used to demonstrate that intercalated ALF795 retains the photoactive behavior of the free CORM, with a substantial fraction (42 %) of the high CO payload (2.46 mmol g–1) being released after exposure to UV light for 3 h under simulated physiological conditions. In addition, gas chromatography was used to track sequential light- and H2O2-triggered decarbonylation of free and intercalated ALF795. In biological buffer solution (HEPES), less than 2 % Mo leaching from Zn,Al-ALF795 took place after 5 h, showing the strong capacity of the LDH host to retain the unaltered complex and decarbonylation fragments.

Original languageEnglish
Pages (from-to)2726-2736
Number of pages11
JournalEuropean Journal of Inorganic Chemistry
Volume2020
Issue number28
DOIs
Publication statusPublished - 31 Jul 2020

Keywords

  • Carbon monoxide
  • Drug delivery
  • Isocyanide ligands
  • Layered compounds
  • Molybdenum

Fingerprint

Dive into the research topics of 'One-Pot Intercalation Strategy for the Encapsulation of a CO-Releasing Organometallic Molecule in a Layered Double Hydroxide'. Together they form a unique fingerprint.

Cite this