While the focus of attention currently is on developing a vaccine against the Coronavirus SARS-CoV-2 to protect against the disease COVID-19, policymakers should prepare for the next challenge: uptake of the vaccine among the public. Having a vaccine does not automatically imply it will be used. Compliance with the anti-H1N1 vaccine during the 2009 influenza pandemic, for instance, was low , and in the decade since, vaccination rates have remained an issue of concern  while vaccination hesitancy has become more prevalent, leading to increases in disease outbreaks in multiple countries . It is, therefore, important to understand whether or not people are willing to be vaccinated against COVID-19, as this can have large consequences for the success a vaccination programme—with potentially large health and economic consequences. In this editorial, we provide some first insights into this willingness to be vaccinated, based on a multi-country European study , which hopefully result in more attention for this important issue.