On the reactivity of mRNA Cap0: C-H oxidative addition of 7-methylguanosine to Pt and base pairing studies

Maria Inês P.S. Leitão; Carmen  González; Giulia Francescato; Zuzanna Filipiak; Ana Petronilho

doi:10.1039/d0cc06075e

On the reactivity of mRNA Cap0: C-H oxidative addition of 7-methylguanosine to Pt and base pairing studies

Maria Inês P.S. Leitão, Carmen González, Giulia Francescato, Zuzanna Filipiak, Ana Petronilho

Instituto de Tecnologia Química e Biológica António Xavier (ITQB)

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Abstract

7-Methylguanosine, whose lability to form an ylide/NHC has been known for decades, reacts with [Pt(PPh3)4] via C-H oxidative addition to yield a hydrido-PtII carbene complex. 1H NMR studies on Watson-Crick base-pairs showed no significant effect of metallation. This journal is

Original language	English
Pages (from-to)	13365-13368
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	87
DOIs	https://doi.org/10.1039/d0cc06075e
Publication status	Published - 11 Nov 2020

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AU - Filipiak, Zuzanna

AU - Petronilho, Ana

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AB - 7-Methylguanosine, whose lability to form an ylide/NHC has been known for decades, reacts with [Pt(PPh3)4] via C-H oxidative addition to yield a hydrido-PtII carbene complex. 1H NMR studies on Watson-Crick base-pairs showed no significant effect of metallation. This journal is

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On the reactivity of mRNA Cap0: C-H oxidative addition of 7-methylguanosine to Pt and base pairing studies

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