In this work we present the toxicological assessment of sixteen ionic liquids (ILs), containing either an imidazolium, or a pyridinium ring, or a cholinium function, to filamentous fungi (Penicillium sp.) as eukaryotic model organisms. It is shown that among this family there are members which show much higher tolerance towards ILs than any other microorganism studied so far. Furthermore, guided by the paradigm that the choice of an ionic liquid as catalyst can alter the outcome of a given chemical reaction, we investigated the ability of ILs to alter the metabolic profile in fungi. The metabolic footprinting, using ESI-MS, revealed that fungal cultures respond to specific liquid salts by changing the cell biochemistry, resulting in a different pattern of secondary metabolites.
|Number of pages||11|
|Journal||ACS Symposium Series|
|Publication status||Published - 28 Apr 2010|
|Event||236th National Meeting and Exposition of the American Chemical Society, ACS 2008 - Philadelpia, PA, United States|
Duration: 17 Aug 2008 → 21 Aug 2008
- Ionic liquids
- Imidazolium ionic