TY - JOUR
T1 - Ocular Sarcoidosis and Autoimmune Polyglandular Syndrome Type 2
T2 - A Case Report
AU - Pinheiro, Rosa Lomelino
AU - Pinheiro, Sara Lomelino
AU - Nunes Silva, Tiago
AU - Canha, Catarina
AU - Fonseca, Maria Cristina Dias Ferrão
AU - Proença, Rui Daniel Mateus Barreiros
N1 - Publisher Copyright:
© 2022 Taylor & Francis Group, LLC.
PY - 2024/1
Y1 - 2024/1
N2 - Purpose: to describe a clinical case of ocular sarcoidosis in a patient with Autoimmune Polyglandular Syndrome Type 2 (APS-2). Methods: an 86-year-old female diagnosed with APS-2 was referred to our uveitis department with rapid visual loss in her left eye during a 3-month period. Her best-corrected visual acuity (BCVA) was counting fingers in her left eye (OS) and 20/40 in her right eye (OD). Slit-lamp biomicroscopy was unremarkable OD but revealed granulomatous keratic precipitates OS. Fundoscopy revealed bilateral optic disc oedema and +2 and 4+ vitritis (SUN classification) in her OD and OS, respectively. Results: the patient underwent chest X-Ray which revealed bilateral hilar lymphadenopathy and fibrosis. On high-resolution computed tomography of the lungs, ground-glass opacities were visible, and a diagnosis of ocular sarcoidosis was presumed. After exclusion of infectious diseases, the patient was treated with methotrexate and oral corticosteroids and there was substantial improvement of the optic nerve oedema and vitritis. At the most recent visit, 2 years later, OS BCVA was 20/50. Conclusion: There may be an association between ocular sarcoidosis and APS or other autoimmune disorders.
AB - Purpose: to describe a clinical case of ocular sarcoidosis in a patient with Autoimmune Polyglandular Syndrome Type 2 (APS-2). Methods: an 86-year-old female diagnosed with APS-2 was referred to our uveitis department with rapid visual loss in her left eye during a 3-month period. Her best-corrected visual acuity (BCVA) was counting fingers in her left eye (OS) and 20/40 in her right eye (OD). Slit-lamp biomicroscopy was unremarkable OD but revealed granulomatous keratic precipitates OS. Fundoscopy revealed bilateral optic disc oedema and +2 and 4+ vitritis (SUN classification) in her OD and OS, respectively. Results: the patient underwent chest X-Ray which revealed bilateral hilar lymphadenopathy and fibrosis. On high-resolution computed tomography of the lungs, ground-glass opacities were visible, and a diagnosis of ocular sarcoidosis was presumed. After exclusion of infectious diseases, the patient was treated with methotrexate and oral corticosteroids and there was substantial improvement of the optic nerve oedema and vitritis. At the most recent visit, 2 years later, OS BCVA was 20/50. Conclusion: There may be an association between ocular sarcoidosis and APS or other autoimmune disorders.
KW - Addison’s disease
KW - autoimmune polyglandular syndrome
KW - ocular sarcoidosis
KW - sarcoidosis
KW - uveitis
UR - http://www.scopus.com/inward/record.url?scp=85138832379&partnerID=8YFLogxK
U2 - 10.1080/09273948.2022.2122513
DO - 10.1080/09273948.2022.2122513
M3 - Article
C2 - 36126065
AN - SCOPUS:85138832379
SN - 0927-3948
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
ER -