Occupational exposure to hexavalent chromium, nickel and PAHs: a mixtures risk assessment approach based on literature exposure data from european countries

Ana Maria Tavares, Susana Viegas, Henriqueta Louro, Thomas Göen, Tiina Santonen, Mirjam Luijten, Andreas Kortenkamp, Maria João Silva

Research output: Contribution to journalArticlepeer-review

Abstract

Hexavalent chromium (Cr(VI)), nickel (Ni) and polycyclic aromatic hydrocarbons (PAHs) are genotoxic co-occurring lung carcinogens whose occupational health risk is still understudied. This study, conducted within the European Human Biomonitoring Initiative (HBM4EU), aimed at performing a mixtures risk assessment (MRA) based on published human biomonitoring (HBM) data from Cr(VI), Ni and/or PAHs occupational co-exposure in Europe. After data extraction, Risk Quotient (RQ) and Sum of Risk Quotients (SRQ) were calculated for binary and ternary mixtures to characterise the risk. Most selected articles measured urinary levels of Cr and Ni and a SRQ > 1 was obtained for co-exposure levels in welding activities, showing that there is concern regarding co-exposure to these substances. Similarly, co-exposure to mixtures of Cr(VI), Ni and PAHs in waste incineration settings resulted in SRQ > 1. In some studies, a low risk was estimated based on the single substances’ exposure level (RQ < 1), but the mixture was considered of concern (SRQ > 1), highlighting the relevance of considering exposure to the mixture rather than to its single components. Overall, this study points out the need of using a MRA based on HBM data as a more realistic approach to assess and manage the risk at the workplace, in order to protect workers’ health.

Original languageEnglish
Article number431
JournalToxics
Volume10
Issue number8
DOIs
Publication statusPublished - 29 Jul 2022

Keywords

  • co-exposure
  • European Human Biomonitoring Initiative (HBM4EU)
  • human biomonitoring (HBM)
  • mixture risk assessment (MRA)
  • workplace

Fingerprint

Dive into the research topics of 'Occupational exposure to hexavalent chromium, nickel and PAHs: a mixtures risk assessment approach based on literature exposure data from european countries'. Together they form a unique fingerprint.

Cite this