Occupational cosmic radiation exposure in Portuguese airline pilots: study of a possible correlation with oxidative biological markers

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Abstract

Several studies have sought to understand the health effects of occupational exposure to cosmic radiation. However, only few biologic markers or associations with disease outcomes have so far been identified. In the present study, 22 long- and 26 medium-haul male Portuguese airline pilots and 36 factory workers who did not fly regularly were investigated. The two groups were comparable in age and diet, were non-smokers, never treated with ionizing radiation and other factors. Cosmic radiation exposure in pilots was quantified based on direct monitoring of 51 flights within Europe, and from Europe to North and South America, and to Africa. Indirect dose estimates in pilots were performed based on the SIEVERT (Syste`me informatise ´ d’e´valuation par vol de l’exposition au rayonnement cosmique dans les transports ae´riens) software for 6,039 medium- and 1,366 long-haul flights. Medium-haul pilots had a higher cosmic radiation dose rate than long-haul pilots, that is, 3.3 ± 0.2 lSv/h and 2.7 ± 0.3 lSv/h, respectively. Biological tests for oxidative stress on blood and urine, as appropriate, at two time periods separated by 1 year, included measurements of antioxidant capacity, total protein, ferritin, hemoglobin, creatinine and 8-hydroxy-2-deoxyguanosine (8OHdG). Principal components analysis was used to discriminate between the exposed and unexposed groups based on all the biological tests. According to this analysis, creatinine and 8OHdG levels were different for the pilots and the unexposed group, but no distinctions could be made among the medium- and the long-haul pilots. While hemoglobin levels seem to be comparable between the studied groups, they were directly correlated with ferritin values, which were lower for the airline pilots.
Original languageUnknown
Pages (from-to)211-220
JournalRadiation And Environmental Biophysics
Volume52
Issue number2
DOIs
Publication statusPublished - 1 Jan 2013

Keywords

    Cite this

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    title = "Occupational cosmic radiation exposure in Portuguese airline pilots: study of a possible correlation with oxidative biological markers",
    abstract = "Several studies have sought to understand the health effects of occupational exposure to cosmic radiation. However, only few biologic markers or associations with disease outcomes have so far been identified. In the present study, 22 long- and 26 medium-haul male Portuguese airline pilots and 36 factory workers who did not fly regularly were investigated. The two groups were comparable in age and diet, were non-smokers, never treated with ionizing radiation and other factors. Cosmic radiation exposure in pilots was quantified based on direct monitoring of 51 flights within Europe, and from Europe to North and South America, and to Africa. Indirect dose estimates in pilots were performed based on the SIEVERT (Syste`me informatise ´ d’e´valuation par vol de l’exposition au rayonnement cosmique dans les transports ae´riens) software for 6,039 medium- and 1,366 long-haul flights. Medium-haul pilots had a higher cosmic radiation dose rate than long-haul pilots, that is, 3.3 ± 0.2 lSv/h and 2.7 ± 0.3 lSv/h, respectively. Biological tests for oxidative stress on blood and urine, as appropriate, at two time periods separated by 1 year, included measurements of antioxidant capacity, total protein, ferritin, hemoglobin, creatinine and 8-hydroxy-2-deoxyguanosine (8OHdG). Principal components analysis was used to discriminate between the exposed and unexposed groups based on all the biological tests. According to this analysis, creatinine and 8OHdG levels were different for the pilots and the unexposed group, but no distinctions could be made among the medium- and the long-haul pilots. While hemoglobin levels seem to be comparable between the studied groups, they were directly correlated with ferritin values, which were lower for the airline pilots.",
    keywords = "Oxidative stress, PCA, Occupational exposure, 8-Hydroxy-2-deoxyguanosine, Commercial aviation, Medium-/long-haul flights",
    author = "Pereira, {Maria Alice Santos} and Silva, {Marco Diogo Richter Gomes da} and Tavares, {Pedro Ant{\'o}nio de Brito}",
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    T1 - Occupational cosmic radiation exposure in Portuguese airline pilots: study of a possible correlation with oxidative biological markers

    AU - Pereira, Maria Alice Santos

    AU - Silva, Marco Diogo Richter Gomes da

    AU - Tavares, Pedro António de Brito

    N1 - Sem PDF

    PY - 2013/1/1

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    N2 - Several studies have sought to understand the health effects of occupational exposure to cosmic radiation. However, only few biologic markers or associations with disease outcomes have so far been identified. In the present study, 22 long- and 26 medium-haul male Portuguese airline pilots and 36 factory workers who did not fly regularly were investigated. The two groups were comparable in age and diet, were non-smokers, never treated with ionizing radiation and other factors. Cosmic radiation exposure in pilots was quantified based on direct monitoring of 51 flights within Europe, and from Europe to North and South America, and to Africa. Indirect dose estimates in pilots were performed based on the SIEVERT (Syste`me informatise ´ d’e´valuation par vol de l’exposition au rayonnement cosmique dans les transports ae´riens) software for 6,039 medium- and 1,366 long-haul flights. Medium-haul pilots had a higher cosmic radiation dose rate than long-haul pilots, that is, 3.3 ± 0.2 lSv/h and 2.7 ± 0.3 lSv/h, respectively. Biological tests for oxidative stress on blood and urine, as appropriate, at two time periods separated by 1 year, included measurements of antioxidant capacity, total protein, ferritin, hemoglobin, creatinine and 8-hydroxy-2-deoxyguanosine (8OHdG). Principal components analysis was used to discriminate between the exposed and unexposed groups based on all the biological tests. According to this analysis, creatinine and 8OHdG levels were different for the pilots and the unexposed group, but no distinctions could be made among the medium- and the long-haul pilots. While hemoglobin levels seem to be comparable between the studied groups, they were directly correlated with ferritin values, which were lower for the airline pilots.

    AB - Several studies have sought to understand the health effects of occupational exposure to cosmic radiation. However, only few biologic markers or associations with disease outcomes have so far been identified. In the present study, 22 long- and 26 medium-haul male Portuguese airline pilots and 36 factory workers who did not fly regularly were investigated. The two groups were comparable in age and diet, were non-smokers, never treated with ionizing radiation and other factors. Cosmic radiation exposure in pilots was quantified based on direct monitoring of 51 flights within Europe, and from Europe to North and South America, and to Africa. Indirect dose estimates in pilots were performed based on the SIEVERT (Syste`me informatise ´ d’e´valuation par vol de l’exposition au rayonnement cosmique dans les transports ae´riens) software for 6,039 medium- and 1,366 long-haul flights. Medium-haul pilots had a higher cosmic radiation dose rate than long-haul pilots, that is, 3.3 ± 0.2 lSv/h and 2.7 ± 0.3 lSv/h, respectively. Biological tests for oxidative stress on blood and urine, as appropriate, at two time periods separated by 1 year, included measurements of antioxidant capacity, total protein, ferritin, hemoglobin, creatinine and 8-hydroxy-2-deoxyguanosine (8OHdG). Principal components analysis was used to discriminate between the exposed and unexposed groups based on all the biological tests. According to this analysis, creatinine and 8OHdG levels were different for the pilots and the unexposed group, but no distinctions could be made among the medium- and the long-haul pilots. While hemoglobin levels seem to be comparable between the studied groups, they were directly correlated with ferritin values, which were lower for the airline pilots.

    KW - Oxidative stress

    KW - PCA

    KW - Occupational exposure

    KW - 8-Hydroxy-2-deoxyguanosine

    KW - Commercial aviation

    KW - Medium-/long-haul flights

    U2 - 10.1007/s00411-013-0460-2

    DO - 10.1007/s00411-013-0460-2

    M3 - Article

    VL - 52

    SP - 211

    EP - 220

    JO - Radiation And Environmental Biophysics

    JF - Radiation And Environmental Biophysics

    SN - 0301-634X

    IS - 2

    ER -