Novel functions for Rab GTPases in multiple aspects of tumour progression

Chiara Recchi, Miguel C Seabra

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Rab GTPases are master regulators of intracellular trafficking and, in recent years, their role in the control of different aspects of tumour progression has emerged. In the present review, we show that Rab GTPases are disregulated in many cancers and have central roles in tumour cell migration, invasion, proliferation, communication with stromal cells and the development of drug resistance. As a consequence, Rab proteins may be novel potential candidates for the development of anticancer drugs and, in this context, the preliminary results obtained with an inhibitor of Rab function are also discussed.
Original languageEnglish
Pages (from-to)1398-1403
Number of pages5
JournalBiochemical Society Transactions
Volume40
Issue numberPart 6
DOIs
Publication statusPublished - 1 Dec 2012

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