Novel cyclic 1,2-diacetals derived from (2R,3R)-(+)-tartaric acid: Synthesis and application as N,O ligands for the enantioselective alkylation of benzaldehyde by diethylzinc

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Abstract

A chiral cyclic 1,2-diacetal derived from tartaric acid was used as the basic structural unit for novel ligands. Monooxazoline carbinols in which the degree of substitution of the alcohol and the nature of the stereocentre in the oxazoline ring were varied were synthesized in moderate to good yields. The influence of these structural factors on asymmetric induction was examined in the enantioselective addition of diethylzinc to benzaldehyde. Up to 60% ee was observed with a secondary or a tertiary alcohol as the metal-chelating group.

Original languageEnglish
Pages (from-to)1820-1829
Number of pages10
JournalEuropean Journal of Organic Chemistry
Issue number8
DOIs
Publication statusPublished - 13 Apr 2004

Keywords

  • Alkylation
  • Asymmetric catalysis
  • Diacetals
  • N,O ligands
  • Zinc

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