Novel biocompatible ionic liquids based on gluconate anion

Alexandra Costa; Andreia Forte; Karolina Zalewska; Gonçalo Tiago; Zeljko Petrovski; Luís C. Branco

doi:10.1080/17518253.2014.951695

Novel biocompatible ionic liquids based on gluconate anion

Alexandra Costa, Andreia Forte, Karolina Zalewska, Gonçalo Tiago, Zeljko Petrovski, Luís C. Branco

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Abstract

A sustainable organic synthetic methodology for the preparation of novel biocompatible ionic liquids (ILs) based on gluconate anion has been developed. Four functionalized methylimidazolium cations were efficiently combined with gluconic acid by acid-base neutralization reactions. All salts were obtained as RTILs in high yields (92–98%) and in high purity levels. Proton Nuclear Magnetic Resonance (¹H NMR) studies had proved the correct cation/ anion proportion (1:1) and their chemical stability. These novel gluconate ILs can be applied for chemistry, material science, and medicine areas.

Original language	English
Pages (from-to)	8-12
Number of pages	5
Journal	Green Chemistry Letters and Reviews
Volume	8
Issue number	1
DOIs	https://doi.org/10.1080/17518253.2014.951695
Publication status	Published - 1 Jan 2015

Keywords

Biocompatible
Gluconate
Ionic liquids

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10.1080/17518253.2014.951695Licence: CC BY

Novel biocompatible ionic liquids based on gluconate anionFinal published version, 459 KBLicence: CC BY

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abstract = "A sustainable organic synthetic methodology for the preparation of novel biocompatible ionic liquids (ILs) based on gluconate anion has been developed. Four functionalized methylimidazolium cations were efficiently combined with gluconic acid by acid-base neutralization reactions. All salts were obtained as RTILs in high yields (92–98%) and in high purity levels. Proton Nuclear Magnetic Resonance (1H NMR) studies had proved the correct cation/ anion proportion (1:1) and their chemical stability. These novel gluconate ILs can be applied for chemistry, material science, and medicine areas.",

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AU - Costa, Alexandra

AU - Forte, Andreia

AU - Zalewska, Karolina

AU - Tiago, Gonçalo

AU - Petrovski, Zeljko

AU - Branco, Luís C.

PY - 2015/1/1

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N2 - A sustainable organic synthetic methodology for the preparation of novel biocompatible ionic liquids (ILs) based on gluconate anion has been developed. Four functionalized methylimidazolium cations were efficiently combined with gluconic acid by acid-base neutralization reactions. All salts were obtained as RTILs in high yields (92–98%) and in high purity levels. Proton Nuclear Magnetic Resonance (1H NMR) studies had proved the correct cation/ anion proportion (1:1) and their chemical stability. These novel gluconate ILs can be applied for chemistry, material science, and medicine areas.

AB - A sustainable organic synthetic methodology for the preparation of novel biocompatible ionic liquids (ILs) based on gluconate anion has been developed. Four functionalized methylimidazolium cations were efficiently combined with gluconic acid by acid-base neutralization reactions. All salts were obtained as RTILs in high yields (92–98%) and in high purity levels. Proton Nuclear Magnetic Resonance (1H NMR) studies had proved the correct cation/ anion proportion (1:1) and their chemical stability. These novel gluconate ILs can be applied for chemistry, material science, and medicine areas.

KW - Biocompatible

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Novel biocompatible ionic liquids based on gluconate anion

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