Novel Approach to Estimate Osteoarthritis Progression

Use of the Reliable Change Index in the Evaluation of Joint Space Loss

Camille M. Parsons, Andrew Judge, Kirsten Leyland, Olivier Bruyère, Florence Petit Dop, Roland Chapurlat, Jean Yves Reginster, Mark H. Edwards, Elaine M. Dennison, Cyrus Cooper, Hazel Inskip, C. Christiansen, P. Delmas, H. Genant, J. Zacher, N. Bellamy, C. Speirs, G. Bréart, O. Meyer, D. Gensburger & 29 others M. Arlot, J. P. Roux, R. Deroisy, P. Sambrook, B. Leeb, A. Verbruggen, W. Bensen, T. Hala, M. Holm-Bentzen, I. Valter, X. Chevalier, B. Swoboda, S. Adami, M. Kloppenburg, E. Grazuleviciute, J. Badurski, J. Branco, E. Nasonov, F. Navarro, T. Spector, L. Barnsley, S. Hall, G. Jones, A. Klestov, L. March, P. Nash, E. Romas, R. Will, L. Erlacher

Research output: Contribution to journalArticle

Abstract

Objective: Osteoarthritis-related changes in joint space measurements over time are small and sensitive to measurement error. The Reliable Change Index (RCI) determines whether the magnitude of change observed in an individual can be attributed to true change. This study aimed to examine the RCI as a novel approach to estimating osteoarthritis progression. Methods: Data were from 167 men and 392 women with knee osteoarthritis (diagnosed using the American College of Rheumatology criteria) randomized to the placebo arm of the 3-year Strontium Ranelate Efficacy in Knee Osteoarthritis trial (SEKOIA) and assessed annually. The RCI was used to determine whether the magnitude of change in joint space width (JSW) on radiographs between study years was likely to be true or due to measurement error. Results: Between consecutive years, 57–69% of participants had an apparent decrease (change <0) in JSW, while 31–43% of participants had annual changes indicating improvement in JSW. The RCI identified JSW decreases in only 6.0% of patients between baseline and year 1, and in 4.5% of patients between the remaining study years. The apparent increases in JSW were almost eliminated between baseline and year 1, and between years 1 and 2 only 1.3% of patients had a significant increase, dropping to 0.9% between years 2 and 3. Conclusion: The RCI provides a method to identify change in JSW, removing many apparent changes that are likely to be due to measurement error. This method appears to be useful for assessing change in JSW from radiographs in clinical and research settings.

Original languageEnglish
Pages (from-to)300-307
Number of pages8
JournalArthritis Care and Research
Volume71
Issue number2
DOIs
Publication statusPublished - 1 Feb 2019

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Osteoarthritis
Joints
Knee Osteoarthritis
strontium ranelate
Placebos
Research

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Parsons, C. M., Judge, A., Leyland, K., Bruyère, O., Petit Dop, F., Chapurlat, R., ... Erlacher, L. (2019). Novel Approach to Estimate Osteoarthritis Progression: Use of the Reliable Change Index in the Evaluation of Joint Space Loss. Arthritis Care and Research, 71(2), 300-307. https://doi.org/10.1002/acr.23596
Parsons, Camille M. ; Judge, Andrew ; Leyland, Kirsten ; Bruyère, Olivier ; Petit Dop, Florence ; Chapurlat, Roland ; Reginster, Jean Yves ; Edwards, Mark H. ; Dennison, Elaine M. ; Cooper, Cyrus ; Inskip, Hazel ; Christiansen, C. ; Delmas, P. ; Genant, H. ; Zacher, J. ; Bellamy, N. ; Speirs, C. ; Bréart, G. ; Meyer, O. ; Gensburger, D. ; Arlot, M. ; Roux, J. P. ; Deroisy, R. ; Sambrook, P. ; Leeb, B. ; Verbruggen, A. ; Bensen, W. ; Hala, T. ; Holm-Bentzen, M. ; Valter, I. ; Chevalier, X. ; Swoboda, B. ; Adami, S. ; Kloppenburg, M. ; Grazuleviciute, E. ; Badurski, J. ; Branco, J. ; Nasonov, E. ; Navarro, F. ; Spector, T. ; Barnsley, L. ; Hall, S. ; Jones, G. ; Klestov, A. ; March, L. ; Nash, P. ; Romas, E. ; Will, R. ; Erlacher, L. / Novel Approach to Estimate Osteoarthritis Progression : Use of the Reliable Change Index in the Evaluation of Joint Space Loss. In: Arthritis Care and Research. 2019 ; Vol. 71, No. 2. pp. 300-307.
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abstract = "Objective: Osteoarthritis-related changes in joint space measurements over time are small and sensitive to measurement error. The Reliable Change Index (RCI) determines whether the magnitude of change observed in an individual can be attributed to true change. This study aimed to examine the RCI as a novel approach to estimating osteoarthritis progression. Methods: Data were from 167 men and 392 women with knee osteoarthritis (diagnosed using the American College of Rheumatology criteria) randomized to the placebo arm of the 3-year Strontium Ranelate Efficacy in Knee Osteoarthritis trial (SEKOIA) and assessed annually. The RCI was used to determine whether the magnitude of change in joint space width (JSW) on radiographs between study years was likely to be true or due to measurement error. Results: Between consecutive years, 57–69{\%} of participants had an apparent decrease (change <0) in JSW, while 31–43{\%} of participants had annual changes indicating improvement in JSW. The RCI identified JSW decreases in only 6.0{\%} of patients between baseline and year 1, and in 4.5{\%} of patients between the remaining study years. The apparent increases in JSW were almost eliminated between baseline and year 1, and between years 1 and 2 only 1.3{\%} of patients had a significant increase, dropping to 0.9{\%} between years 2 and 3. Conclusion: The RCI provides a method to identify change in JSW, removing many apparent changes that are likely to be due to measurement error. This method appears to be useful for assessing change in JSW from radiographs in clinical and research settings.",
author = "Parsons, {Camille M.} and Andrew Judge and Kirsten Leyland and Olivier Bruy{\`e}re and {Petit Dop}, Florence and Roland Chapurlat and Reginster, {Jean Yves} and Edwards, {Mark H.} and Dennison, {Elaine M.} and Cyrus Cooper and Hazel Inskip and C. Christiansen and P. Delmas and H. Genant and J. Zacher and N. Bellamy and C. Speirs and G. Br{\'e}art and O. Meyer and D. Gensburger and M. Arlot and Roux, {J. P.} and R. Deroisy and P. Sambrook and B. Leeb and A. Verbruggen and W. Bensen and T. Hala and M. Holm-Bentzen and I. Valter and X. Chevalier and B. Swoboda and S. Adami and M. Kloppenburg and E. Grazuleviciute and J. Badurski and J. Branco and E. Nasonov and F. Navarro and T. Spector and L. Barnsley and S. Hall and G. Jones and A. Klestov and L. March and P. Nash and E. Romas and R. Will and L. Erlacher",
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Parsons, CM, Judge, A, Leyland, K, Bruyère, O, Petit Dop, F, Chapurlat, R, Reginster, JY, Edwards, MH, Dennison, EM, Cooper, C, Inskip, H, Christiansen, C, Delmas, P, Genant, H, Zacher, J, Bellamy, N, Speirs, C, Bréart, G, Meyer, O, Gensburger, D, Arlot, M, Roux, JP, Deroisy, R, Sambrook, P, Leeb, B, Verbruggen, A, Bensen, W, Hala, T, Holm-Bentzen, M, Valter, I, Chevalier, X, Swoboda, B, Adami, S, Kloppenburg, M, Grazuleviciute, E, Badurski, J, Branco, J, Nasonov, E, Navarro, F, Spector, T, Barnsley, L, Hall, S, Jones, G, Klestov, A, March, L, Nash, P, Romas, E, Will, R & Erlacher, L 2019, 'Novel Approach to Estimate Osteoarthritis Progression: Use of the Reliable Change Index in the Evaluation of Joint Space Loss', Arthritis Care and Research, vol. 71, no. 2, pp. 300-307. https://doi.org/10.1002/acr.23596

Novel Approach to Estimate Osteoarthritis Progression : Use of the Reliable Change Index in the Evaluation of Joint Space Loss. / Parsons, Camille M.; Judge, Andrew; Leyland, Kirsten; Bruyère, Olivier; Petit Dop, Florence; Chapurlat, Roland; Reginster, Jean Yves; Edwards, Mark H.; Dennison, Elaine M.; Cooper, Cyrus; Inskip, Hazel; Christiansen, C.; Delmas, P.; Genant, H.; Zacher, J.; Bellamy, N.; Speirs, C.; Bréart, G.; Meyer, O.; Gensburger, D.; Arlot, M.; Roux, J. P.; Deroisy, R.; Sambrook, P.; Leeb, B.; Verbruggen, A.; Bensen, W.; Hala, T.; Holm-Bentzen, M.; Valter, I.; Chevalier, X.; Swoboda, B.; Adami, S.; Kloppenburg, M.; Grazuleviciute, E.; Badurski, J.; Branco, J.; Nasonov, E.; Navarro, F.; Spector, T.; Barnsley, L.; Hall, S.; Jones, G.; Klestov, A.; March, L.; Nash, P.; Romas, E.; Will, R.; Erlacher, L.

In: Arthritis Care and Research, Vol. 71, No. 2, 01.02.2019, p. 300-307.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Novel Approach to Estimate Osteoarthritis Progression

T2 - Use of the Reliable Change Index in the Evaluation of Joint Space Loss

AU - Parsons, Camille M.

AU - Judge, Andrew

AU - Leyland, Kirsten

AU - Bruyère, Olivier

AU - Petit Dop, Florence

AU - Chapurlat, Roland

AU - Reginster, Jean Yves

AU - Edwards, Mark H.

AU - Dennison, Elaine M.

AU - Cooper, Cyrus

AU - Inskip, Hazel

AU - Christiansen, C.

AU - Delmas, P.

AU - Genant, H.

AU - Zacher, J.

AU - Bellamy, N.

AU - Speirs, C.

AU - Bréart, G.

AU - Meyer, O.

AU - Gensburger, D.

AU - Arlot, M.

AU - Roux, J. P.

AU - Deroisy, R.

AU - Sambrook, P.

AU - Leeb, B.

AU - Verbruggen, A.

AU - Bensen, W.

AU - Hala, T.

AU - Holm-Bentzen, M.

AU - Valter, I.

AU - Chevalier, X.

AU - Swoboda, B.

AU - Adami, S.

AU - Kloppenburg, M.

AU - Grazuleviciute, E.

AU - Badurski, J.

AU - Branco, J.

AU - Nasonov, E.

AU - Navarro, F.

AU - Spector, T.

AU - Barnsley, L.

AU - Hall, S.

AU - Jones, G.

AU - Klestov, A.

AU - March, L.

AU - Nash, P.

AU - Romas, E.

AU - Will, R.

AU - Erlacher, L.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Objective: Osteoarthritis-related changes in joint space measurements over time are small and sensitive to measurement error. The Reliable Change Index (RCI) determines whether the magnitude of change observed in an individual can be attributed to true change. This study aimed to examine the RCI as a novel approach to estimating osteoarthritis progression. Methods: Data were from 167 men and 392 women with knee osteoarthritis (diagnosed using the American College of Rheumatology criteria) randomized to the placebo arm of the 3-year Strontium Ranelate Efficacy in Knee Osteoarthritis trial (SEKOIA) and assessed annually. The RCI was used to determine whether the magnitude of change in joint space width (JSW) on radiographs between study years was likely to be true or due to measurement error. Results: Between consecutive years, 57–69% of participants had an apparent decrease (change <0) in JSW, while 31–43% of participants had annual changes indicating improvement in JSW. The RCI identified JSW decreases in only 6.0% of patients between baseline and year 1, and in 4.5% of patients between the remaining study years. The apparent increases in JSW were almost eliminated between baseline and year 1, and between years 1 and 2 only 1.3% of patients had a significant increase, dropping to 0.9% between years 2 and 3. Conclusion: The RCI provides a method to identify change in JSW, removing many apparent changes that are likely to be due to measurement error. This method appears to be useful for assessing change in JSW from radiographs in clinical and research settings.

AB - Objective: Osteoarthritis-related changes in joint space measurements over time are small and sensitive to measurement error. The Reliable Change Index (RCI) determines whether the magnitude of change observed in an individual can be attributed to true change. This study aimed to examine the RCI as a novel approach to estimating osteoarthritis progression. Methods: Data were from 167 men and 392 women with knee osteoarthritis (diagnosed using the American College of Rheumatology criteria) randomized to the placebo arm of the 3-year Strontium Ranelate Efficacy in Knee Osteoarthritis trial (SEKOIA) and assessed annually. The RCI was used to determine whether the magnitude of change in joint space width (JSW) on radiographs between study years was likely to be true or due to measurement error. Results: Between consecutive years, 57–69% of participants had an apparent decrease (change <0) in JSW, while 31–43% of participants had annual changes indicating improvement in JSW. The RCI identified JSW decreases in only 6.0% of patients between baseline and year 1, and in 4.5% of patients between the remaining study years. The apparent increases in JSW were almost eliminated between baseline and year 1, and between years 1 and 2 only 1.3% of patients had a significant increase, dropping to 0.9% between years 2 and 3. Conclusion: The RCI provides a method to identify change in JSW, removing many apparent changes that are likely to be due to measurement error. This method appears to be useful for assessing change in JSW from radiographs in clinical and research settings.

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DO - 10.1002/acr.23596

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SP - 300

EP - 307

JO - Arthritis Care & Research

JF - Arthritis Care & Research

SN - 2151-464X

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ER -