Normal genetic response to gamma irradiation in familial adenomatous polyposis

A. Bras, L. Cristóvão, C. Coelho, A. Hilali, B. Dutrillaux, A. Léonard, J. Rueff

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The present study, a co-operative project between three European institutes, was aimed at elucidating whether the APC gene in carriers of familial adenomatous polyposis coli (FAP) also causes some genetic sensitivity revealed by DNA damage and the yield of chromosome aberrations in peripheral blood lymphocytes exposed to gamma rays. In addition, it seemed of interest to study whether DNA repair is modified after irradiation of lymphocytes from FAP patients compared to controls. To this end, we have used the inhibition of the poly(ADP-ribose) polymerase (ADPRP) by 3-aminobenzamide (3ABA) and studied the effect of 3ABA on the frequency of DNA strand breaks and chromosome aberrations. The data indicate that FAP is not associated with an increased chromosomal sensitivity towards ionising radiation.

Original languageEnglish
Pages (from-to)1506-1510
Number of pages5
JournalEuropean journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
Volume31
Issue number9
DOIs
Publication statusPublished - 1995

Keywords

  • chromosomal aberrations
  • DNA strand breaks
  • familial adenomatous polyposis
  • gamma rays
  • poly(ADP-ribose) polymerase

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