Non-viral strategies for ocular gene delivery

A.V. Oliveira, A.M. Rosa da Costa, G.A. Silva

Research output: Contribution to journalReview articlepeer-review

62 Citations (Scopus)


The success of gene therapy relies on efficient gene transfer and stable transgene expression. The in vivo efficiency is determined by the delivery vector, route of administration, therapeutic gene, and target cells. While some requirements are common to several strategies, others depend on the target disease and transgene product. Consequently, it is unlikely that a single system is suitable for all applications. This review examines current gene therapy strategies, focusing on non-viral approaches and the use of natural polymers with the eye, and particularly the retina, as their gene delivery target. © 2017 Elsevier B.V.
Original languageEnglish
Pages (from-to)1275-1289
Number of pages15
JournalMaterials Science and Engineering C
Publication statusPublished - Aug 2017


  • Eye
  • Gene therapy
  • Non-viral vectors
  • Retina
  • Gene expression
  • Gene transfer
  • Genes
  • Natural polymers
  • Delivery vector
  • Gene Delivery
  • Nonviral vectors
  • Target cells
  • Therapeutic genes
  • Therapy strategies
  • Transgene expression


Dive into the research topics of 'Non-viral strategies for ocular gene delivery'. Together they form a unique fingerprint.

Cite this