Abstract
Background: Most clinical isolates that exhibit a multi-drug resistant phenotype owe that resistance to over-expressed efflux pumps. Compounds that are efflux pump inhibitors (EPIs) reduce or reverse resistance to antibiotics to which the bacterial strain is initially resistant. We have evaluated non-antibiotics to reduce resistance of commonly encountered bacterial pathogens to antibiotics. Materials and Methods: The effect of non-antibiotics on the susceptibility of bacteria to antibiotics was conducted by minimum inhibition concentration determinations of the antibiotic in the absence and presence of the non-antibiotic. Results: Non-antibiotics such as chlorpromazine, amitryptiline and transchlorprothixene are shown to reduce or reverse resistance of a variety of bacteria to antibiotics. Conclusion: The results suggest that non-antibiotics may serve as adjuncts to conventional antibiotics for the therapy of problematic antibiotic infections caused by bacteria that owe their resistance to over-expressed efflux pumps.
Original language | English |
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Pages (from-to) | 751-754 |
Number of pages | 4 |
Journal | In Vivo |
Volume | 24 |
Issue number | 5 |
Publication status | Published - Sept 2010 |
Keywords
- Non-antibiotics
- Bacteria
- Antibiotics
- Reversal of resistance