NMR Techniques for the Study of Transient Intermolecular Interactions

Jesús Angulo, Ana Ardá, Eurico J. Cabrita, Manuel Martín-Pastor, Jesús Jiménez-Barbero, Pedro M. Nieto

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Citations (Scopus)


NMR is one of the most versatile techniques for the analysis of molecular interactions. In this review we cover the main techniques and applications of the ligand-observed methods: transfer-NOESY, Saturation Transfer Difference NMR and Diffusion NMR. They have in common that monitoring the signals of the small molecule, used in high excess, allowed to obtain information about the ligand within the transient complex.

Original languageEnglish
Title of host publicationStructure Elucidation in Organic Chemistry
Subtitle of host publicationThe Search for the Right Tools
Number of pages36
ISBN (Electronic)9783527664610
ISBN (Print)9783527333363
Publication statusPublished - 27 Apr 2015


  • Diffusion
  • Epitope mapping
  • Ligand-observed Techniques
  • NMR
  • Transfer-NOE
  • Transient complexes


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