NMR Techniques for the Study of Transient Intermolecular Interactions

Jesús Angulo, Ana Ardá, Eurico J. Cabrita, Manuel Martín-Pastor, Jesús Jiménez-Barbero, Pedro M. Nieto

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

NMR is one of the most versatile techniques for the analysis of molecular interactions. In this review we cover the main techniques and applications of the ligand-observed methods: transfer-NOESY, Saturation Transfer Difference NMR and Diffusion NMR. They have in common that monitoring the signals of the small molecule, used in high excess, allowed to obtain information about the ligand within the transient complex.

Original languageEnglish
Title of host publicationStructure Elucidation in Organic Chemistry
Subtitle of host publicationThe Search for the Right Tools
PublisherWILEY-BLACKWELL
Pages325-360
Number of pages36
ISBN (Electronic)9783527664610
ISBN (Print)9783527333363
DOIs
Publication statusPublished - 27 Apr 2015

Fingerprint

Nuclear magnetic resonance
Ligands
Molecular interactions
Molecules
Monitoring

Keywords

  • Diffusion
  • Epitope mapping
  • Ligand-observed Techniques
  • NMR
  • STD-NMR
  • Transfer-NOE
  • Transient complexes

Cite this

Angulo, J., Ardá, A., Cabrita, E. J., Martín-Pastor, M., Jiménez-Barbero, J., & Nieto, P. M. (2015). NMR Techniques for the Study of Transient Intermolecular Interactions. In Structure Elucidation in Organic Chemistry: The Search for the Right Tools (pp. 325-360). WILEY-BLACKWELL. https://doi.org/10.1002/9783527664610.ch9
Angulo, Jesús ; Ardá, Ana ; Cabrita, Eurico J. ; Martín-Pastor, Manuel ; Jiménez-Barbero, Jesús ; Nieto, Pedro M. / NMR Techniques for the Study of Transient Intermolecular Interactions. Structure Elucidation in Organic Chemistry: The Search for the Right Tools. WILEY-BLACKWELL, 2015. pp. 325-360
@inbook{5fcfc74dc9264bab902818626b383e0e,
title = "NMR Techniques for the Study of Transient Intermolecular Interactions",
abstract = "NMR is one of the most versatile techniques for the analysis of molecular interactions. In this review we cover the main techniques and applications of the ligand-observed methods: transfer-NOESY, Saturation Transfer Difference NMR and Diffusion NMR. They have in common that monitoring the signals of the small molecule, used in high excess, allowed to obtain information about the ligand within the transient complex.",
keywords = "Diffusion, Epitope mapping, Ligand-observed Techniques, NMR, STD-NMR, Transfer-NOE, Transient complexes",
author = "Jes{\'u}s Angulo and Ana Ard{\'a} and Cabrita, {Eurico J.} and Manuel Mart{\'i}n-Pastor and Jes{\'u}s Jim{\'e}nez-Barbero and Nieto, {Pedro M.}",
note = "Sem PDF.",
year = "2015",
month = "4",
day = "27",
doi = "10.1002/9783527664610.ch9",
language = "English",
isbn = "9783527333363",
pages = "325--360",
booktitle = "Structure Elucidation in Organic Chemistry",
publisher = "WILEY-BLACKWELL",

}

Angulo, J, Ardá, A, Cabrita, EJ, Martín-Pastor, M, Jiménez-Barbero, J & Nieto, PM 2015, NMR Techniques for the Study of Transient Intermolecular Interactions. in Structure Elucidation in Organic Chemistry: The Search for the Right Tools. WILEY-BLACKWELL, pp. 325-360. https://doi.org/10.1002/9783527664610.ch9

NMR Techniques for the Study of Transient Intermolecular Interactions. / Angulo, Jesús; Ardá, Ana; Cabrita, Eurico J.; Martín-Pastor, Manuel; Jiménez-Barbero, Jesús; Nieto, Pedro M.

Structure Elucidation in Organic Chemistry: The Search for the Right Tools. WILEY-BLACKWELL, 2015. p. 325-360.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - NMR Techniques for the Study of Transient Intermolecular Interactions

AU - Angulo, Jesús

AU - Ardá, Ana

AU - Cabrita, Eurico J.

AU - Martín-Pastor, Manuel

AU - Jiménez-Barbero, Jesús

AU - Nieto, Pedro M.

N1 - Sem PDF.

PY - 2015/4/27

Y1 - 2015/4/27

N2 - NMR is one of the most versatile techniques for the analysis of molecular interactions. In this review we cover the main techniques and applications of the ligand-observed methods: transfer-NOESY, Saturation Transfer Difference NMR and Diffusion NMR. They have in common that monitoring the signals of the small molecule, used in high excess, allowed to obtain information about the ligand within the transient complex.

AB - NMR is one of the most versatile techniques for the analysis of molecular interactions. In this review we cover the main techniques and applications of the ligand-observed methods: transfer-NOESY, Saturation Transfer Difference NMR and Diffusion NMR. They have in common that monitoring the signals of the small molecule, used in high excess, allowed to obtain information about the ligand within the transient complex.

KW - Diffusion

KW - Epitope mapping

KW - Ligand-observed Techniques

KW - NMR

KW - STD-NMR

KW - Transfer-NOE

KW - Transient complexes

UR - http://www.scopus.com/inward/record.url?scp=84926482872&partnerID=8YFLogxK

U2 - 10.1002/9783527664610.ch9

DO - 10.1002/9783527664610.ch9

M3 - Chapter

SN - 9783527333363

SP - 325

EP - 360

BT - Structure Elucidation in Organic Chemistry

PB - WILEY-BLACKWELL

ER -

Angulo J, Ardá A, Cabrita EJ, Martín-Pastor M, Jiménez-Barbero J, Nieto PM. NMR Techniques for the Study of Transient Intermolecular Interactions. In Structure Elucidation in Organic Chemistry: The Search for the Right Tools. WILEY-BLACKWELL. 2015. p. 325-360 https://doi.org/10.1002/9783527664610.ch9