New neo-Clerodanes from Tinnea antiscorbutica Welv.

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Abstract

Three new neo-clerodanes, antiscorbuticane A, antiscorbuticane B and antiscorbuticane C, and known compounds glutinol, friedelin, 5,7-dihydroxyflavanone (pinocembrin), 5-hydroxy-3,6,7,4'-tetramethoxyflavone, 5-hydroxy-3,6,7,3',4'-pentamethoxyflavone (artemetin), 5,4'-dihydroxy-3,6,7,3'-tetramethoxyflavone (penduletin) and 5,3',4'-trihydroxy-3,6,7-trimethoxyflavone (chrysosplenol D), were isolated from the methanol extract of Tinnea antiscorbutica. Antiscorbuticane B exhibited no mutagenic activity at doses of up to 250 mu g per plate (Ames test) and did not induce micronucleus formation in the V79 cell line at doses of up to 100 mu g mL(-1).
Original languageEnglish
Pages (from-to)1950-1956
Number of pages7
JournalJournal Of The Brazilian Chemical Society
Volume24
Issue number12
DOIs
Publication statusPublished - 2013

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