TY - JOUR
T1 - New neo-Clerodanes from Tinnea antiscorbutica Welv.
AU - Gaspar, Jorge
AU - Martins, Célia
AU - Rueff, J.
PY - 2013
Y1 - 2013
N2 - Three new neo-clerodanes, antiscorbuticane A, antiscorbuticane B and antiscorbuticane C, and known compounds glutinol, friedelin, 5,7-dihydroxyflavanone (pinocembrin), 5-hydroxy-3,6,7,4'-tetramethoxyflavone, 5-hydroxy-3,6,7,3',4'-pentamethoxyflavone (artemetin), 5,4'-dihydroxy-3,6,7,3'-tetramethoxyflavone (penduletin) and 5,3',4'-trihydroxy-3,6,7-trimethoxyflavone (chrysosplenol D), were isolated from the methanol extract of Tinnea antiscorbutica. Antiscorbuticane B exhibited no mutagenic activity at doses of up to 250 mu g per plate (Ames test) and did not induce micronucleus formation in the V79 cell line at doses of up to 100 mu g mL(-1).
AB - Three new neo-clerodanes, antiscorbuticane A, antiscorbuticane B and antiscorbuticane C, and known compounds glutinol, friedelin, 5,7-dihydroxyflavanone (pinocembrin), 5-hydroxy-3,6,7,4'-tetramethoxyflavone, 5-hydroxy-3,6,7,3',4'-pentamethoxyflavone (artemetin), 5,4'-dihydroxy-3,6,7,3'-tetramethoxyflavone (penduletin) and 5,3',4'-trihydroxy-3,6,7-trimethoxyflavone (chrysosplenol D), were isolated from the methanol extract of Tinnea antiscorbutica. Antiscorbuticane B exhibited no mutagenic activity at doses of up to 250 mu g per plate (Ames test) and did not induce micronucleus formation in the V79 cell line at doses of up to 100 mu g mL(-1).
KW - CANCER-CELLS
KW - genotoxicity
KW - mutagenic activity
KW - DITERPENOIDS
KW - APOPTOSIS
KW - Tinnea antiscorbutica
KW - PINOCEMBRIN
KW - cytotoxic activity
KW - neo-clerodanes
KW - FLAVONOIDS
KW - GLUTINOL
KW - CHEMICAL-CONSTITUENTS
U2 - 10.5935/0103-5053.20130244
DO - 10.5935/0103-5053.20130244
M3 - Article
SN - 0103-5053
VL - 24
SP - 1950
EP - 1956
JO - Journal Of The Brazilian Chemical Society
JF - Journal Of The Brazilian Chemical Society
IS - 12
ER -