New Low-Toxicity Cholinium-Based Ionic Liquids with Perfluoroalkanoate Anions for Aqueous Biphasic System Implementation

David J S Patinha, Liliana C. Tomé, Catarina Florindo, Hugo R. Soares, Ana S. Coroadinha, Isabel M. Marrucho

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

This work explores the widening of properties of cholinium-based ionic liquids (ILs) through their combination with perfluoroalkanoate anions so that higher number of aqueous biphasic systems (ABSs) containing nontoxic cholinium-based ILs is available. For that purpose, six cholinium perfluoroalkanoate ILs were synthesized and their cytotoxicity was evaluated using three different animal cell lines, envisaging biotechnology applications. Ternary phase equilibrium data for ABSs composed of the cholinium perfluoroalkanoate, with fluoroalkyl chains from C2 up to C7, using a strong salting out agent, K3PO4, were determined at 25 °C. The results show the relevant role of the size of fluorinated alkyl chain length in the anion since, contrary to other ABSs containing ILs with increasing alkyl chain length in the anion, the ABSs with cholinium perfluoroalkanoates present well-spaced solubility curves, allowing the conclusion that these ABSs can be tuned by a proper choice of the IL. The phase splitting mechanism was also disclosed through water activity measurements.

Original languageEnglish
Pages (from-to)2670-2679
Number of pages10
JournalACS SUSTAINABLE CHEMISTRY & ENGINEERING
Volume4
Issue number5
DOIs
Publication statusPublished - 2 May 2016

Keywords

  • Aqueous biphasic systems
  • Cholinium perfluoroalkanoate ionic liquids
  • Cytotoxicity and biocompatibility
  • KPO
  • Phase diagrams

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