Neutropénia crónica benigna da infância

Translated title of the contribution: Chronic benign neutropenia of childhood

Ana Paula Azevedo, Cristina Gamelas, Valdemar Teixeira, Marta Contreiras, Rita Monteiro, Maria Gorete Vale, Fernando Durães

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The term neutropenia concerns the reduction of the amount of circulating neutrophils in peripheric blood. The Chronic Benign Neutropenia of Childhood (CBNC) is characterized by the presence of a circulating neutrophils total number (absolute count) below 1,5 x 10(9)L, for over a six-month period. The diagnosis is established when the laboratorial changes occur during the first two years of life, without previous history of serious infections, nor neutrophils morphological changes, nor hypocellular bone marrow examination. The cellularity is normal or increased and a neutrophil maturation arrest at some phase can be observed. Generally, the whole process is solved by the age of four. Because this is a very rare clinical situation, it justifies a bibliographic revision about the theme. We present the clinical case of a 15 month-old-child, admitted with fever and diarrhea associated with neutropenia. Bone marrow aspiration, other laboratorial exams carried out during hospital internment and presented clinical evolution were consistent with CBNC diagnosis.
Translated title of the contributionChronic benign neutropenia of childhood
Original languagePortuguese
Pages (from-to)521-526
Number of pages6
JournalActa Médica Portuguesa
Issue number3
Publication statusPublished - May 2010


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