TY - JOUR
T1 - Natural polymorphisms of HIV type 2 pol sequences from drug-naive individuals
AU - Parreira, Ricardo
AU - Monteiro, Filipa
AU - Pádua, Elizabeth
AU - Piedade, João
AU - Venenno, Teresa
AU - Paixão, Maria Teresa
AU - Esteves, Aida
PY - 2006/11/1
Y1 - 2006/11/1
N2 - Until today, the susceptibility of human immunodeficiency virus type 2 (HIV-2) to protease and nucleosidic reverse-transcriptase inhibitors (PI and NRTI, respectively) has not been clearly documented. In this report we studied HIV-2 proviral sequences (n = 30) from drug-naive patients. Our results revealed that several amino acid positions in the protease and reverse transcriptase coding sequence harbored residues that have been associated with drug resistance in HIV-1-infected patients. In particular, the M46I substitution in the protease was detected in 90% of the sequences analyzed, which, together with the other substitutions identified, may indicate a reduced susceptibility of HIV-2-infected drug-naive patients to PI. Furthermore, interpretation of genotypic data with four available algorithms, developed for interpretation of HIV-1 sequence data, suggested nonoverlapping profiles of drug resistance.
AB - Until today, the susceptibility of human immunodeficiency virus type 2 (HIV-2) to protease and nucleosidic reverse-transcriptase inhibitors (PI and NRTI, respectively) has not been clearly documented. In this report we studied HIV-2 proviral sequences (n = 30) from drug-naive patients. Our results revealed that several amino acid positions in the protease and reverse transcriptase coding sequence harbored residues that have been associated with drug resistance in HIV-1-infected patients. In particular, the M46I substitution in the protease was detected in 90% of the sequences analyzed, which, together with the other substitutions identified, may indicate a reduced susceptibility of HIV-2-infected drug-naive patients to PI. Furthermore, interpretation of genotypic data with four available algorithms, developed for interpretation of HIV-1 sequence data, suggested nonoverlapping profiles of drug resistance.
UR - http://www.scopus.com/inward/record.url?scp=33845458777&partnerID=8YFLogxK
UR - https://www.liebertpub.com/doi/10.1089/aid.2006.22.1178?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
U2 - 10.1089/aid.2006.22.1178
DO - 10.1089/aid.2006.22.1178
M3 - Article
C2 - 17147507
AN - SCOPUS:33845458777
SN - 0889-2229
VL - Vol. 22
SP - 1178
EP - 1182
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
IS - n.º 11
ER -
