Natural polymorphisms of HIV type 2 pol sequences from drug-naive individuals

Ricardo Parreira, Filipa Monteiro, Elizabeth Pádua, João Piedade, Teresa Venenno, Maria Teresa Paixão, Aida Esteves

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10 Citations (Scopus)

Abstract

Until today, the susceptibility of human immunodeficiency virus type 2 (HIV-2) to protease and nucleosidic reverse-transcriptase inhibitors (PI and NRTI, respectively) has not been clearly documented. In this report we studied HIV-2 proviral sequences (n = 30) from drug-naive patients. Our results revealed that several amino acid positions in the protease and reverse transcriptase coding sequence harbored residues that have been associated with drug resistance in HIV-1-infected patients. In particular, the M46I substitution in the protease was detected in 90% of the sequences analyzed, which, together with the other substitutions identified, may indicate a reduced susceptibility of HIV-2-infected drug-naive patients to PI. Furthermore, interpretation of genotypic data with four available algorithms, developed for interpretation of HIV-1 sequence data, suggested nonoverlapping profiles of drug resistance.

Original languageEnglish
Pages (from-to)1178-1182
Number of pages5
JournalAIDS Research and Human Retroviruses
VolumeVol. 22
Issue numbern.º 11
DOIs
Publication statusPublished - 1 Nov 2006

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