Natural frequency of polymorphisms linked to the chondroitin 4-sulfotransferase genes and its association with placental malaria

B. Valente; P. A. Campos; Virgilio Estólio do Rosário; Henrique Manuel Condinho da Silveira

doi:10.1016/j.trstmh.2010.05.005

Natural frequency of polymorphisms linked to the chondroitin 4-sulfotransferase genes and its association with placental malaria

B. Valente, P. A. Campos, Virgilio Estólio do Rosário, Henrique Manuel Condinho da Silveira

Research output: Contribution to journal › Article › peer-review

Abstract

Our understanding about the role of the maternal genetic factors on placental malaria is scarce. The general aim of this work was to examine whether common polymorphisms of genes involved in chondroitin sulphate A (CSA) synthesis influence susceptibility to and manifestation of malaria during pregnancy. To achieve this, 96 women with placental malaria and 180 healthy controls without malaria from the province of Luanda, Angola, were genotyped using six microsatellite loci. No associations were found between polymorphisms of genes involved in CSA synthesis and placental malaria. All these findings suggest that there is no genetic susceptibility or increased risk attributed to polymorphisms of the enzymes involved on the synthesis of CSA. (C) 2010 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

Original language	Unknown
Pages (from-to)	687-689
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	104
Issue number	10
DOIs	https://doi.org/10.1016/j.trstmh.2010.05.005
Publication status	Published - 1 Jan 2010

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10.1016/j.trstmh.2010.05.005

Cite this

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title = "Natural frequency of polymorphisms linked to the chondroitin 4-sulfotransferase genes and its association with placental malaria",

abstract = "Our understanding about the role of the maternal genetic factors on placental malaria is scarce. The general aim of this work was to examine whether common polymorphisms of genes involved in chondroitin sulphate A (CSA) synthesis influence susceptibility to and manifestation of malaria during pregnancy. To achieve this, 96 women with placental malaria and 180 healthy controls without malaria from the province of Luanda, Angola, were genotyped using six microsatellite loci. No associations were found between polymorphisms of genes involved in CSA synthesis and placental malaria. All these findings suggest that there is no genetic susceptibility or increased risk attributed to polymorphisms of the enzymes involved on the synthesis of CSA. (C) 2010 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.",

keywords = "Plasmodium, A, 4-sulfotransferase, Angola, chondroitin, sulphate, Placental, polymorphism, malaria, Luanda, falciparum",

author = "B. Valente and Campos, {P. A.} and Ros{\'a}rio, {Virgilio Est{\'o}lio do} and Silveira, {Henrique Manuel Condinho da}",

year = "2010",

month = jan,

day = "1",

doi = "10.1016/j.trstmh.2010.05.005",

language = "Unknown",

volume = "104",

pages = "687--689",

journal = "Transactions of the Royal Society of Tropical Medicine and Hygiene",

issn = "0035-9203",

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Natural frequency of polymorphisms linked to the chondroitin 4-sulfotransferase genes and its association with placental malaria. / Valente, B.; Campos, P. A.; Rosário, Virgilio Estólio do et al.
In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 104, No. 10, 01.01.2010, p. 687-689.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Natural frequency of polymorphisms linked to the chondroitin 4-sulfotransferase genes and its association with placental malaria

AU - Valente, B.

AU - Campos, P. A.

AU - Rosário, Virgilio Estólio do

AU - Silveira, Henrique Manuel Condinho da

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Our understanding about the role of the maternal genetic factors on placental malaria is scarce. The general aim of this work was to examine whether common polymorphisms of genes involved in chondroitin sulphate A (CSA) synthesis influence susceptibility to and manifestation of malaria during pregnancy. To achieve this, 96 women with placental malaria and 180 healthy controls without malaria from the province of Luanda, Angola, were genotyped using six microsatellite loci. No associations were found between polymorphisms of genes involved in CSA synthesis and placental malaria. All these findings suggest that there is no genetic susceptibility or increased risk attributed to polymorphisms of the enzymes involved on the synthesis of CSA. (C) 2010 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

AB - Our understanding about the role of the maternal genetic factors on placental malaria is scarce. The general aim of this work was to examine whether common polymorphisms of genes involved in chondroitin sulphate A (CSA) synthesis influence susceptibility to and manifestation of malaria during pregnancy. To achieve this, 96 women with placental malaria and 180 healthy controls without malaria from the province of Luanda, Angola, were genotyped using six microsatellite loci. No associations were found between polymorphisms of genes involved in CSA synthesis and placental malaria. All these findings suggest that there is no genetic susceptibility or increased risk attributed to polymorphisms of the enzymes involved on the synthesis of CSA. (C) 2010 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

KW - Plasmodium

KW - A

KW - 4-sulfotransferase

KW - Angola

KW - chondroitin

KW - sulphate

KW - Placental

KW - polymorphism

KW - malaria

KW - Luanda

KW - falciparum

U2 - 10.1016/j.trstmh.2010.05.005

DO - 10.1016/j.trstmh.2010.05.005

M3 - Article

C2 - 20580388

SN - 0035-9203

VL - 104

SP - 687

EP - 689

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

IS - 10

ER -