Nanoparticles for mass spectrometry applications

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Nanotechnology has led to the development of new and improved materials, and particular emphasis has been directed toward nanoparticles and their multiple bio-applications. Nanoparticles exhibit size-, shape-, and compositiondependent properties, e.g., surface plasmon resonance and photothermal properties, which may potentially enhance laser desorption/ionization systems for mass spectrometry-based analysis of biomolecules. Also, nanoparticles possess high surface to volume ratio that can be easily derivatized with a wide range of ligands with different functional groups. Surface modification makes nanoparticles advantageous for sample preparation procedures prior to detection by mass spectrometry. Moreover, it allows the synthesis of affinity probes, which promotes interactions between nanoparticles and analytes, greatly enhancing the ionization efficiency. This chapter provides a comprehensive discussion on the use of nanoparticles for mass spectrometry-related applications, from sample preparation methodologies to ionization surfaces. Applications will focus on nanoparticle size, composition, and functionalization, as a comparative point of view on optimal characteristics toward maximization of bioassay efficiency.

Original languageEnglish
Title of host publicationHandbook of Nanoparticles
PublisherSPRINGER INTERNATIONAL PUBLISHING AG
Pages1371-1396
Number of pages26
ISBN (Electronic)9783319153384
ISBN (Print)9783319153377
DOIs
Publication statusPublished - 18 Sep 2015

Fingerprint

Nanoparticles
Mass spectrometry
Mass Spectrometry
Ionization
Nanotechnology
Surface Plasmon Resonance
Bioassay
Surface plasmon resonance
Biomolecules
Biological Assay
Functional groups
Surface treatment
Desorption
Lasers
Ligands
Chemical analysis

Keywords

  • Affinity probes
  • Mass spectrometry
  • Nanoparticles
  • SALDI
  • Surface functionalization

Cite this

Larguinho, M., Capelo, J. L., & Baptista, P. V. (2015). Nanoparticles for mass spectrometry applications. In Handbook of Nanoparticles (pp. 1371-1396). SPRINGER INTERNATIONAL PUBLISHING AG. https://doi.org/10.1007/978-3-319-15338-4_32
Larguinho, Miguel ; Capelo, José Luís ; Baptista, Pedro V. / Nanoparticles for mass spectrometry applications. Handbook of Nanoparticles. SPRINGER INTERNATIONAL PUBLISHING AG, 2015. pp. 1371-1396
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Larguinho, M, Capelo, JL & Baptista, PV 2015, Nanoparticles for mass spectrometry applications. in Handbook of Nanoparticles. SPRINGER INTERNATIONAL PUBLISHING AG, pp. 1371-1396. https://doi.org/10.1007/978-3-319-15338-4_32

Nanoparticles for mass spectrometry applications. / Larguinho, Miguel; Capelo, José Luís; Baptista, Pedro V.

Handbook of Nanoparticles. SPRINGER INTERNATIONAL PUBLISHING AG, 2015. p. 1371-1396.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Larguinho M, Capelo JL, Baptista PV. Nanoparticles for mass spectrometry applications. In Handbook of Nanoparticles. SPRINGER INTERNATIONAL PUBLISHING AG. 2015. p. 1371-1396 https://doi.org/10.1007/978-3-319-15338-4_32