Nanoparticle Drug Delivery Systems: Recent Patents and Applications in Nanomedicine

Pedro Martins, Daniela Rosa, Alexandra R. Fernandes, Pedro Baptista

Research output: Contribution to journalArticle

Abstract

Traditional methods of drug delivery present several drawbacks, mainly due to off-target effects that may originate severe side and toxic effect to healthy tissues. Parallel to the development of novel more effective drugs, particular effort has been dedicated to develop and optimize drug delivery vehicles capable of specifically targeting the required tissue/organ and to deliver the cargo only where and when it is needed. New drug delivery systems based on nanoscale devices showing new and improved pharmacokinetic and pharmacodynamics properties like enhanced bioavailability, high drug loading or systemic stability have surged in the past decade as promising solutions to the required therapeutic efficacy. Amongst these nanoscale vectors, nanoparticles for drug delivery, such as polymeric, lipidbased, ceramic or metallic nanoparticles, have been at the forefront of pharmaceutical development. The interest in nanomedicine for treatment and diagnosis is clearly reflected on the increasing number of publications and issued patents every year. Here, we provide a broad overview of novel nanoparticle based drug delivery systems, ranging from polymeric systems to metal nanoparticles, while simultaneously listing the most relevant related patents.
Original languageEnglish
Pages (from-to)105-118
Number of pages14
JournalRecent Patents on Nanomedicine
Volume3
Issue number2
DOIs
Publication statusPublished - Jan 2013

Fingerprint

Nanomedicine
Medical nanotechnology
Patents
Drug Delivery Systems
Drug delivery
Nanoparticles
Pharmacodynamics
Pharmaceutical Preparations
Metal Nanoparticles
Tissue
Pharmacokinetics
Metal nanoparticles
Poisons
Drug products
Ceramics
Biological Availability
Publications
Equipment and Supplies
Therapeutics

Keywords

  • Cancer
  • drug carriers
  • drug targeting
  • nanomedicine
  • nanoparticles
  • nanotechnology
  • patents

Cite this

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title = "Nanoparticle Drug Delivery Systems: Recent Patents and Applications in Nanomedicine",
abstract = "Traditional methods of drug delivery present several drawbacks, mainly due to off-target effects that may originate severe side and toxic effect to healthy tissues. Parallel to the development of novel more effective drugs, particular effort has been dedicated to develop and optimize drug delivery vehicles capable of specifically targeting the required tissue/organ and to deliver the cargo only where and when it is needed. New drug delivery systems based on nanoscale devices showing new and improved pharmacokinetic and pharmacodynamics properties like enhanced bioavailability, high drug loading or systemic stability have surged in the past decade as promising solutions to the required therapeutic efficacy. Amongst these nanoscale vectors, nanoparticles for drug delivery, such as polymeric, lipidbased, ceramic or metallic nanoparticles, have been at the forefront of pharmaceutical development. The interest in nanomedicine for treatment and diagnosis is clearly reflected on the increasing number of publications and issued patents every year. Here, we provide a broad overview of novel nanoparticle based drug delivery systems, ranging from polymeric systems to metal nanoparticles, while simultaneously listing the most relevant related patents.",
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Nanoparticle Drug Delivery Systems: Recent Patents and Applications in Nanomedicine. / Martins, Pedro; Rosa, Daniela; Fernandes, Alexandra R.; Baptista, Pedro.

In: Recent Patents on Nanomedicine, Vol. 3, No. 2, 01.2013, p. 105-118.

Research output: Contribution to journalArticle

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