N-Heterocyclic Carbenes Derived from Guanosine: Synthesis and Evidences of Their Antiproliferative Activity

Maria Inês P.S. Leitão; Federico Herrera; Ana Petronilho

doi:10.1021/acsomega.8b02387

N-Heterocyclic Carbenes Derived from Guanosine: Synthesis and Evidences of Their Antiproliferative Activity

Maria Inês P.S. Leitão, Federico Herrera, Ana Petronilho

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Abstract

Palladium(II) and platinum(II) complexes bearing N-heterocyclic carbenes derived from guanosine are synthesized via oxidative addition, followed by protonation in the presence of acid. Cytotoxicity of the compounds is evaluated in several cell lines. Compounds 2a, 2b, and 3a are selective for glioblastoma U251 cells and are nontoxic toward healthy human embryonic kidney (HEK293) cells.

Original language	English
Pages (from-to)	15653-15656
Number of pages	4
Journal	ACS Omega
Volume	3
Issue number	11
DOIs	https://doi.org/10.1021/acsomega.8b02387
Publication status	Published - 16 Nov 2018

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10.1021/acsomega.8b02387Licence: CC BY-NC

N‑Heterocyclic Carbenes Derived from Guanosine Synthesis andFinal published version, 1.02 MBLicence: CC BY-NC

https://pubs.acs.org/doi/10.1021/acsomega.8b02387Licence: CC BY-NC

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abstract = "Palladium(II) and platinum(II) complexes bearing N-heterocyclic carbenes derived from guanosine are synthesized via oxidative addition, followed by protonation in the presence of acid. Cytotoxicity of the compounds is evaluated in several cell lines. Compounds 2a, 2b, and 3a are selective for glioblastoma U251 cells and are nontoxic toward healthy human embryonic kidney (HEK293) cells.",

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AU - Petronilho, Ana

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N-Heterocyclic Carbenes Derived from Guanosine: Synthesis and Evidences of Their Antiproliferative Activity

Abstract

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