N-Heterocyclic Carbenes Derived from Guanosine

Synthesis and Evidences of Their Antiproliferative Activity

Maria Inês P.S. Leitão, Federico Herrera, Ana Petronilho

Research output: Contribution to journalArticle

1 Citation (Scopus)
4 Downloads (Pure)

Abstract

Palladium(II) and platinum(II) complexes bearing N-heterocyclic carbenes derived from guanosine are synthesized via oxidative addition, followed by protonation in the presence of acid. Cytotoxicity of the compounds is evaluated in several cell lines. Compounds 2a, 2b, and 3a are selective for glioblastoma U251 cells and are nontoxic toward healthy human embryonic kidney (HEK293) cells.

Original languageEnglish
Pages (from-to)15653-15656
Number of pages4
JournalACS Omega
Volume3
Issue number11
DOIs
Publication statusPublished - 16 Nov 2018

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Bearings (structural)
Guanosine
Protonation
Palladium
Cytotoxicity
Platinum
Cells
Acids
carbene

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N-Heterocyclic Carbenes Derived from Guanosine : Synthesis and Evidences of Their Antiproliferative Activity. / Leitão, Maria Inês P.S.; Herrera, Federico; Petronilho, Ana.

In: ACS Omega, Vol. 3, No. 11, 16.11.2018, p. 15653-15656.

Research output: Contribution to journalArticle

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