TY - JOUR
T1 - Multinational evidence-based recommendations for the diagnosis and management of gout
T2 - Integrating systematic literature review and expert opinion of a broad panel of rheumatologists in the 3e initiative
AU - Sivera, Francisca
AU - Andrés, Mariano
AU - Carmona, Loreto
AU - Kydd, Alison S.R.
AU - Moi, John
AU - Seth, Rakhi
AU - Sriranganathan, Melonie
AU - Van Durme, Caroline
AU - Van Echteld, Irene
AU - Vinik, Ophir
AU - Wechalekar, Mihir D.
AU - Aletaha, Daniel
AU - Bombardier, Claire
AU - Buchbinder, Rachelle
AU - Edwards, Christopher J.
AU - Landewé, Robert B.
AU - Bijlsma, Johannes W.
AU - Branco, Jaime C.
AU - Burgos-Vargas, Rubén
AU - Catrina, Anca I.
AU - Elewaut, Dirk
AU - Ferrari, Antonio J.L.
AU - Kiely, Patrick
AU - Leeb, Burkhard F.
AU - Montecucco, Carlomaurizio
AU - Müller-Ladner, Ulf
AU - Østergaard, Mikkel
AU - Zochling, Jane
AU - Falzon, Louise
AU - Van Der Heijde, Désirée M.
PY - 2014/2
Y1 - 2014/2
N2 - We aimed to develop evidence-based multinational recommendations for the diagnosis and management of gout. Using a formal voting process, a panel of 78 international rheumatologists developed 10 key clinical questions pertinent to the diagnosis and management of gout. Each question was investigated with a systematic literature review. Medline, Embase, Cochrane CENTRAL and abstracts from 2010-2011 European League Against Rheumatism and American College of Rheumatology meetings were searched in each review. Relevant studies were independently reviewed by two individuals for data extraction and synthesis and risk of bias assessment. Using this evidence, rheumatologists from 14 countries (Europe, South America and Australasia) developed national recommendations. After rounds of discussion and voting, multinational recommendations were formulated. Each recommendation was graded according to the level of evidence. Agreement and potential impact on clinical practice were assessed. Combining evidence and clinical expertise, 10 recommendations were produced. One recommendation referred to the diagnosis of gout, two referred to cardiovascular and renal comorbidities, six focused on different aspects of the management of gout (including drug treatment and monitoring), and the last recommendation referred to the management of asymptomatic hyperuricaemia. The level of agreement with the recommendations ranged from 8.1 to 9.2 (mean 8.7) on a 1-10 scale, with 10 representing full agreement. Ten recommendations on the diagnosis and management of gout were established. They are evidence-based and supported by a large panel of rheumatologists from 14 countries, enhancing their utility in clinical practice.
AB - We aimed to develop evidence-based multinational recommendations for the diagnosis and management of gout. Using a formal voting process, a panel of 78 international rheumatologists developed 10 key clinical questions pertinent to the diagnosis and management of gout. Each question was investigated with a systematic literature review. Medline, Embase, Cochrane CENTRAL and abstracts from 2010-2011 European League Against Rheumatism and American College of Rheumatology meetings were searched in each review. Relevant studies were independently reviewed by two individuals for data extraction and synthesis and risk of bias assessment. Using this evidence, rheumatologists from 14 countries (Europe, South America and Australasia) developed national recommendations. After rounds of discussion and voting, multinational recommendations were formulated. Each recommendation was graded according to the level of evidence. Agreement and potential impact on clinical practice were assessed. Combining evidence and clinical expertise, 10 recommendations were produced. One recommendation referred to the diagnosis of gout, two referred to cardiovascular and renal comorbidities, six focused on different aspects of the management of gout (including drug treatment and monitoring), and the last recommendation referred to the management of asymptomatic hyperuricaemia. The level of agreement with the recommendations ranged from 8.1 to 9.2 (mean 8.7) on a 1-10 scale, with 10 representing full agreement. Ten recommendations on the diagnosis and management of gout were established. They are evidence-based and supported by a large panel of rheumatologists from 14 countries, enhancing their utility in clinical practice.
UR - http://www.scopus.com/inward/record.url?scp=84891743514&partnerID=8YFLogxK
U2 - 10.1136/annrheumdis-2013-203325
DO - 10.1136/annrheumdis-2013-203325
M3 - Article
C2 - 23868909
AN - SCOPUS:84891743514
SN - 0003-4967
VL - 73
SP - 328
EP - 335
JO - Annals of the rheumatic diseases
JF - Annals of the rheumatic diseases
IS - 2
ER -