Multilevel impacts of iron in the brain

the cross talk between neurophysiological mechanisms, cognition, and social behavior

Research output: Contribution to journalReview article

1 Citation (Scopus)
1 Downloads (Pure)

Abstract

Iron is a critical element for most organisms, which plays a fundamental role in the great majority of physiological processes. So much so, that disruption of iron homeostasis has severe multi-organ impacts with the brain being particularly sensitive to such modifications. More specifically, disruption of iron homeostasis in the brain can affect neurophysiological mechanisms, cognition, and social behavior, which eventually contributes to the development of a diverse set of neuro-pathologies. This article starts by exploring the mechanisms of iron action in the brain and follows with a discussion on cognitive and behavioral implications of iron deficiency and overload and how these are framed by the social context. Subsequently, we scrutinize the implications of the disruption of iron homeostasis for the onset and progression of psychosocial disorders. Lastly, we discuss the links between biological, psychological, and social dimensions and outline potential avenues of research. The study of these interactions could ultimately contribute to a broader understanding of how individuals think and act under physiological and pathophysiological conditions.

Original languageEnglish
Article number126
JournalPharmaceuticals
Volume12
Issue number3
DOIs
Publication statusPublished - 1 Sep 2019

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Social Behavior
Cognition
Iron
Brain
Homeostasis
Physiological Phenomena
Iron Overload
Pathology
Psychology
Research

Keywords

  • Brain
  • Cognition
  • Iron
  • Neurophysiology
  • Social behavior

Cite this

@article{f749cf99062a4ffeba38162dc4eaf943,
title = "Multilevel impacts of iron in the brain: the cross talk between neurophysiological mechanisms, cognition, and social behavior",
abstract = "Iron is a critical element for most organisms, which plays a fundamental role in the great majority of physiological processes. So much so, that disruption of iron homeostasis has severe multi-organ impacts with the brain being particularly sensitive to such modifications. More specifically, disruption of iron homeostasis in the brain can affect neurophysiological mechanisms, cognition, and social behavior, which eventually contributes to the development of a diverse set of neuro-pathologies. This article starts by exploring the mechanisms of iron action in the brain and follows with a discussion on cognitive and behavioral implications of iron deficiency and overload and how these are framed by the social context. Subsequently, we scrutinize the implications of the disruption of iron homeostasis for the onset and progression of psychosocial disorders. Lastly, we discuss the links between biological, psychological, and social dimensions and outline potential avenues of research. The study of these interactions could ultimately contribute to a broader understanding of how individuals think and act under physiological and pathophysiological conditions.",
keywords = "Brain, Cognition, Iron, Neurophysiology, Social behavior",
author = "Ana Ferreira and Pedro Neves and Raffaella Gozzelino",
note = "Funding agencies: A.F. is funded by national funds through the FCT – Funda{\cc}{\~a}o para a Ci{\^e}ncia e a Tecnologia, I.P., under the Norma Transit{\'o}ria – DL57/2016/CP1453/CT0077, and receives research funding from FCT/MCTES grant PTDC/IVC-ESCT/0073/2014. PN is funded through FCT – Funda{\cc}{\~a}o para a Ci{\^e}ncia e a Tecnologia (UID/ECO/00124/2013, UID/ECO/00124/2019 and Social Sciences DataLab, LISBOA-01-0145-FEDER-022209), POR Lisboa (LISBOA-01-0145-FEDER-007722, LISBOA-01-0145-FEDER-022209), and POR Norte (LISBOA-01-0145-FEDER-022209). RG is funded by FCT – Funda{\cc}{\~a}o para a Ci{\^e}ncia e a Tecnologia (IF/01495/2015) and receives research funding from FCT-PAC (03/SAICT/2015) and EOS MODEL-IDI 30826052. A.F., P.N., and R.G. also received research funding from Santander Totta/NOVA University of Lisbon (Collaborative Investigation Price 2017).",
year = "2019",
month = "9",
day = "1",
doi = "10.3390/ph12030126",
language = "English",
volume = "12",
journal = "Pharmaceuticals",
issn = "1424-8247",
publisher = "Molecular Diversity Preservation International (MDPI)",
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TY - JOUR

T1 - Multilevel impacts of iron in the brain

T2 - the cross talk between neurophysiological mechanisms, cognition, and social behavior

AU - Ferreira, Ana

AU - Neves, Pedro

AU - Gozzelino, Raffaella

N1 - Funding agencies: A.F. is funded by national funds through the FCT – Fundação para a Ciência e a Tecnologia, I.P., under the Norma Transitória – DL57/2016/CP1453/CT0077, and receives research funding from FCT/MCTES grant PTDC/IVC-ESCT/0073/2014. PN is funded through FCT – Fundação para a Ciência e a Tecnologia (UID/ECO/00124/2013, UID/ECO/00124/2019 and Social Sciences DataLab, LISBOA-01-0145-FEDER-022209), POR Lisboa (LISBOA-01-0145-FEDER-007722, LISBOA-01-0145-FEDER-022209), and POR Norte (LISBOA-01-0145-FEDER-022209). RG is funded by FCT – Fundação para a Ciência e a Tecnologia (IF/01495/2015) and receives research funding from FCT-PAC (03/SAICT/2015) and EOS MODEL-IDI 30826052. A.F., P.N., and R.G. also received research funding from Santander Totta/NOVA University of Lisbon (Collaborative Investigation Price 2017).

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Iron is a critical element for most organisms, which plays a fundamental role in the great majority of physiological processes. So much so, that disruption of iron homeostasis has severe multi-organ impacts with the brain being particularly sensitive to such modifications. More specifically, disruption of iron homeostasis in the brain can affect neurophysiological mechanisms, cognition, and social behavior, which eventually contributes to the development of a diverse set of neuro-pathologies. This article starts by exploring the mechanisms of iron action in the brain and follows with a discussion on cognitive and behavioral implications of iron deficiency and overload and how these are framed by the social context. Subsequently, we scrutinize the implications of the disruption of iron homeostasis for the onset and progression of psychosocial disorders. Lastly, we discuss the links between biological, psychological, and social dimensions and outline potential avenues of research. The study of these interactions could ultimately contribute to a broader understanding of how individuals think and act under physiological and pathophysiological conditions.

AB - Iron is a critical element for most organisms, which plays a fundamental role in the great majority of physiological processes. So much so, that disruption of iron homeostasis has severe multi-organ impacts with the brain being particularly sensitive to such modifications. More specifically, disruption of iron homeostasis in the brain can affect neurophysiological mechanisms, cognition, and social behavior, which eventually contributes to the development of a diverse set of neuro-pathologies. This article starts by exploring the mechanisms of iron action in the brain and follows with a discussion on cognitive and behavioral implications of iron deficiency and overload and how these are framed by the social context. Subsequently, we scrutinize the implications of the disruption of iron homeostasis for the onset and progression of psychosocial disorders. Lastly, we discuss the links between biological, psychological, and social dimensions and outline potential avenues of research. The study of these interactions could ultimately contribute to a broader understanding of how individuals think and act under physiological and pathophysiological conditions.

KW - Brain

KW - Cognition

KW - Iron

KW - Neurophysiology

KW - Social behavior

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U2 - 10.3390/ph12030126

DO - 10.3390/ph12030126

M3 - Review article

VL - 12

JO - Pharmaceuticals

JF - Pharmaceuticals

SN - 1424-8247

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M1 - 126

ER -