@inproceedings{fcf3261997db445b8c0032cd505f7fa0,
title = "Multi-level dynamic modeling in biological systems: Application of hybrid Petri nets to network simulation",
abstract = "The recent progress in the high-throughput experimental technologies allows the reconstruction of many biological networks and to evaluate changes in proteins, genes and metabolites levels in different conditions. On the other hand, computational models, when complemented with regulatory information, can be used to predict the phenotype of an organism under different genetic and environmental conditions. These computational methods can be used for example to identify molecular targets capable of inactivating a bacterium and to understand its virulence factors. This work proposes a hybrid metabolic-regulatory Petri net approach that is based on the combination of approximate enzyme-kinetic rate laws and Petri nets. A prototypic network model is used as a test-case to illustrate the application of these concepts in Systems Biology.",
keywords = "Approximate rate laws, Hybrid Petri net, Integrated dynamic modelling, Streptococcus pneumoniae, Systems biology",
author = "Costa, {Rafael S.} and Daniel Machado and Neves, {A. R.} and Susana Vinga",
year = "2012",
language = "English",
isbn = "9789898425904",
series = "BIOINFORMATICS 2012 - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms",
pages = "317--321",
booktitle = "BIOINFORMATICS 2012 - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms",
note = "International Conference on Bioinformatics Models, Methods and Algorithms, BIOINFORMATICS 2012 ; Conference date: 01-02-2012 Through 04-02-2012",
}