Mononuclear Molybdenum-Containing Enzymes

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Molybdenum is essential to the great majority of organisms, being found in the active site of prokaryotic and eukaryotic enzymes that catalyze, in general, oxidation–reduction reactions, involving the transfer of an oxygen or sulfur or hydrogen atom. In the mononuclear molybdenum-containing enzymes, the active site harbors one molybdenum ion coordinated by one or two pyranopterin cofactor molecules. The metal coordination sphere is completed by oxygen and/or sulfur and/or selenium atoms, in a diversity of arrangements, that is the base of the classification of these molybdoenzymes into three large families, denominated after one benchmark enzyme: the xanthine oxidase family, the sulfite oxidase family, and the dimethylsulfoxide reductase family. This article provides an overview of the three families of mononuclear-molybdenum containing enzymes, focusing on the structural and mechanistic aspects of the best-characterized members.
Original languageEnglish
Title of host publicationReference Module in Chemistry, Molecular Sciences and Chemical Engineering
PublisherElsevier Ltd
Pages1-19
Number of pages19
DOIs
Publication statusPublished - 5 Nov 2018

Keywords

  • Aldehyde oxidoreductase
  • Carbon dioxide reduction
  • Dimethylsulfoxide reductase
  • Formate dehydrogenase
  • Hydride transfer
  • Hydroxylation
  • Molybdenum
  • Nitrate reductase
  • Oxidoreductase
  • Oxotransferases
  • Redox
  • Sulfite oxidase
  • anthine oxidase

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  • Cite this

    Maia, L., & Moura, J. J. G. (2018). Mononuclear Molybdenum-Containing Enzymes. In Reference Module in Chemistry, Molecular Sciences and Chemical Engineering (pp. 1-19). Elsevier Ltd. https://doi.org/10.1016/B978-0-12-409547-2.13932-0