TY - JOUR
T1 - Molybdenum and tungsten-containing formate dehydrogenases
T2 - Aiming to inspire a catalyst for carbon dioxide utilization
AU - Maia, Luisa B.
AU - Moura, Isabel
AU - Moura, Jos� J.G.
N1 - Sem PDF.
Unidade de Ciencias Biomoleculares Aplicadas-UCIBIO - national funds from FCT/MEC (UID/Multi/04378/2013)
ERDF (POCI-01-0145-FEDER-007728)
Fundacao para a Ciencia e a Tecnologia, MEC (SFRH/BPD/111404/2015)
Fundacao para a Ciencia e a Tecnologia, MEC (FSE)
PY - 2017/1/30
Y1 - 2017/1/30
N2 - The global energy demand and the present high dependence on fossil fuels have caused an unprecedented increase in the Earth's atmosphere carbon dioxide concentration. Its exponential and uncontrollable rise is responsible for large and unpredictable impacts on the world climate and for ocean acidification, thus, being a major concern for the ecosystems and human's daily life. On the other hand, the carbon dioxide abundance and low cost make it an interesting source for the production of chemical feedstocks and fuels. Yet, the thermodynamic and kinetic stability of the carbon dioxide molecule makes its utilization a laboratorial/industrially challenging task. In this Review, we propose to use the molybdenum and tungsten-containing formate dehydrogenase (FDH) enzymes as a model to understand the mechanistic strategies and key chemical features needed to reduce carbon dioxide to formate. We will highlight the present knowledge about the structure of FDHs, with particular emphasis on active site features, reaction mechanism and ability to reduce carbon dioxide to formate. The information gathered aims to inspire the development of new efficient (bio)catalysts for the atmospheric carbon dioxide utilization, to produce energy and chemical feedstocks, while reducing an important environmental pollutant.
AB - The global energy demand and the present high dependence on fossil fuels have caused an unprecedented increase in the Earth's atmosphere carbon dioxide concentration. Its exponential and uncontrollable rise is responsible for large and unpredictable impacts on the world climate and for ocean acidification, thus, being a major concern for the ecosystems and human's daily life. On the other hand, the carbon dioxide abundance and low cost make it an interesting source for the production of chemical feedstocks and fuels. Yet, the thermodynamic and kinetic stability of the carbon dioxide molecule makes its utilization a laboratorial/industrially challenging task. In this Review, we propose to use the molybdenum and tungsten-containing formate dehydrogenase (FDH) enzymes as a model to understand the mechanistic strategies and key chemical features needed to reduce carbon dioxide to formate. We will highlight the present knowledge about the structure of FDHs, with particular emphasis on active site features, reaction mechanism and ability to reduce carbon dioxide to formate. The information gathered aims to inspire the development of new efficient (bio)catalysts for the atmospheric carbon dioxide utilization, to produce energy and chemical feedstocks, while reducing an important environmental pollutant.
KW - Biocatalyst
KW - Carbon dioxide reduction
KW - Formate dehydrogenase
KW - Greener energy forms
KW - Molybdenum
KW - Tungsten
UR - http://www.scopus.com/inward/record.url?scp=84997282949&partnerID=8YFLogxK
U2 - 10.1016/j.ica.2016.07.010
DO - 10.1016/j.ica.2016.07.010
M3 - Review article
AN - SCOPUS:84997282949
SN - 0020-1693
VL - 455
SP - 350
EP - 363
JO - Inorganica Chimica Acta
JF - Inorganica Chimica Acta
ER -