Molecular epidemiology of HIV-1 infected migrants followed up in portugal: trends between 2001–2017

Victor Pimentel, Marta Pingarilho, Daniela Alves , Isabel Diogo, Sandra Fernandes, Mafalda Miranda, AC Pineda-Peña, Pieter Libin, MR Martins, AM Vandamme, Ricardo Jorge Camacho, Perpétua Gomes, AB Abecasis

Research output: Contribution to journalArticle

Abstract

Objectives: To identify long-term trends in HIV-1 molecular epidemiology and antiretroviral drug resistance (ARV) among migrants followed up in Portugal Methods: 5177 patients were included between 2001 and 2017. Rega, Scuel, Comet, and jPHMM algorithms were used for subtyping. Transmitted drug resistance (TDR) and Acquired drug resistance (ADR) were defined as the presence of surveillance drug resistance mutations (SDRMs) and as mutations of the IAS-USA 2015 algorithm, respectively. Statistical analyses were performed.

Results: HIV-1 subtypes infecting migrants were consistent with the ones prevailing in their countries of origin. Over time, overall TDR significantly increased and specifically for Non-nucleoside reverse transcriptase inhibitor (NNRTIs) and Nucleoside reverse transcriptase inhibitor (NRTIs). TDR was higher in patients from Mozambique. Country of origin Mozambique and subtype B were independently associated with TDR. Overall, ADR significantly decreased over time and specifically for NRTIs and Protease Inhibitors (PIs). Age, subtype B, and viral load were independently associated with ADR.

Conclusions: HIV-1 molecular epidemiology in migrants suggests high levels of connectivity with their country of origin. The increasing levels of TDR in migrants could indicate an increase also in their countries of origin, where more efficient surveillance should occur.
Original languageEnglish
Article number268
Pages (from-to)268-283
Number of pages15
JournalVIRUSES-BASEL
VolumeVol. 12
Issue numbern.º 3
DOIs
Publication statusPublished - Feb 2020

Keywords

  • HIV drug resistance mutations
  • Migrants
  • Molecular epidemiology

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