Modelling the biodegradation of non-steroidal anti-inflammatory drugs (NSAIDs) by activated sludge and a pure culture

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Abstract

A model describing ibuprofen and ketoprofen biodegradation by activated sludge from three different wastewater treatment plants (WWTP) was developed in this study. This model successfully described the biodegradation profiles observed at two different initial concentrations of each compound, where a lag-phase was observed prior to the biodegradation of each compound. Twelve ibuprofen and ketoprofen degrading isolates were identified in this study from the WWTP sludge showing the best removal performance. One of these isolates was characterised via another model, where biodegradation was dependent on biomass growth rate as well as the ibuprofen concentration. The fact that different models were needed to describe the biodegradation by activated sludge and a pure culture suggests that the biodegradation of non-steroidal anti-inflammatory drugs (NSAIDs) depends on the microbial community, thus pharmaceutical biodegradation models may require adaptation depending upon the system. This study provides an advance towards modelling pharmaceutical biodegradation in WWTPs.
Original languageEnglish
Pages (from-to)31-37
JournalBioresource Technology
Volume133
DOIs
Publication statusPublished - Apr 2013

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Biodegradation
activated sludge
biodegradation
drug
Anti-Inflammatory Agents
Pharmaceutical Preparations
modeling
Ibuprofen
Ketoprofen
Wastewater treatment
Drug products
microbial community
Biomass
sludge
biomass

Keywords

  • Activated sludge modelling (ASM)
  • Micropollutants
  • Pharmaceutical active compounds (PhACs) removal kinetics
  • Pure cultures
  • Xenobiotics

Cite this

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title = "Modelling the biodegradation of non-steroidal anti-inflammatory drugs (NSAIDs) by activated sludge and a pure culture",
abstract = "A model describing ibuprofen and ketoprofen biodegradation by activated sludge from three different wastewater treatment plants (WWTP) was developed in this study. This model successfully described the biodegradation profiles observed at two different initial concentrations of each compound, where a lag-phase was observed prior to the biodegradation of each compound. Twelve ibuprofen and ketoprofen degrading isolates were identified in this study from the WWTP sludge showing the best removal performance. One of these isolates was characterised via another model, where biodegradation was dependent on biomass growth rate as well as the ibuprofen concentration. The fact that different models were needed to describe the biodegradation by activated sludge and a pure culture suggests that the biodegradation of non-steroidal anti-inflammatory drugs (NSAIDs) depends on the microbial community, thus pharmaceutical biodegradation models may require adaptation depending upon the system. This study provides an advance towards modelling pharmaceutical biodegradation in WWTPs.",
keywords = "Pure cultures, removal kinetics, Micropollutants, Xenobiotics, Pharmaceutical active compounds (PhACs), Activated sludge modelling (ASM), Activated sludge modelling (ASM), Micropollutants, Pharmaceutical active compounds (PhACs) removal kinetics, Pure cultures, Xenobiotics",
author = "B{\'a}rbara Almeida and Oehmen, {Adrian Michael} and Ricardo Marques and Dulce Brito and Gilda Carvalho and {Goul{\~a}o Crespo}, {Maria Teresa Barreto}",
note = "Sem PDF conforme o despacho. The authors thank IBET/ASU for excellent technical assistance. Fundacao para a Ciencia e Tecnologia is acknowledged for funding through Projects PTDC/EBB-EBI/098862/2008, PEst-OE/EQB/LA0004/2011 and PEst-C/EQB/LA0006/2011, Grants SFRH/BD/47748/2008 and SFRH/BPD/30800/2006.",
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T1 - Modelling the biodegradation of non-steroidal anti-inflammatory drugs (NSAIDs) by activated sludge and a pure culture

AU - Almeida, Bárbara

AU - Oehmen, Adrian Michael

AU - Marques, Ricardo

AU - Brito, Dulce

AU - Carvalho, Gilda

AU - Goulão Crespo, Maria Teresa Barreto

N1 - Sem PDF conforme o despacho. The authors thank IBET/ASU for excellent technical assistance. Fundacao para a Ciencia e Tecnologia is acknowledged for funding through Projects PTDC/EBB-EBI/098862/2008, PEst-OE/EQB/LA0004/2011 and PEst-C/EQB/LA0006/2011, Grants SFRH/BD/47748/2008 and SFRH/BPD/30800/2006.

PY - 2013/4

Y1 - 2013/4

N2 - A model describing ibuprofen and ketoprofen biodegradation by activated sludge from three different wastewater treatment plants (WWTP) was developed in this study. This model successfully described the biodegradation profiles observed at two different initial concentrations of each compound, where a lag-phase was observed prior to the biodegradation of each compound. Twelve ibuprofen and ketoprofen degrading isolates were identified in this study from the WWTP sludge showing the best removal performance. One of these isolates was characterised via another model, where biodegradation was dependent on biomass growth rate as well as the ibuprofen concentration. The fact that different models were needed to describe the biodegradation by activated sludge and a pure culture suggests that the biodegradation of non-steroidal anti-inflammatory drugs (NSAIDs) depends on the microbial community, thus pharmaceutical biodegradation models may require adaptation depending upon the system. This study provides an advance towards modelling pharmaceutical biodegradation in WWTPs.

AB - A model describing ibuprofen and ketoprofen biodegradation by activated sludge from three different wastewater treatment plants (WWTP) was developed in this study. This model successfully described the biodegradation profiles observed at two different initial concentrations of each compound, where a lag-phase was observed prior to the biodegradation of each compound. Twelve ibuprofen and ketoprofen degrading isolates were identified in this study from the WWTP sludge showing the best removal performance. One of these isolates was characterised via another model, where biodegradation was dependent on biomass growth rate as well as the ibuprofen concentration. The fact that different models were needed to describe the biodegradation by activated sludge and a pure culture suggests that the biodegradation of non-steroidal anti-inflammatory drugs (NSAIDs) depends on the microbial community, thus pharmaceutical biodegradation models may require adaptation depending upon the system. This study provides an advance towards modelling pharmaceutical biodegradation in WWTPs.

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