Modelling low energy electron and positron tracks in biologically relevant media

Francisco J. Blanco, Antonio Muñoz, Diogo Almeida, F. F. da Silva, Paulo Manuel Assis Loureiro Limão-vieira, Martina C. Fuss, Ana G. Sanz, Gustavo García

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

This colloquium describes an approach to incorporate into radiation damage models the effect of low and intermediate energy (0-100 eV) electrons and positrons, slowing down in biologically relevant materials (water and representative biomolecules). The core of the modelling procedure is a C++ computing programme named "Low Energy Particle Track Simulation (LEPTS)", which is compatible with available general purpose Monte Carlo packages. Input parameters are carefully selected from theoretical and experimental cross section data and energy loss distribution functions. Data sources used for this purpose are reviewed showing examples of electron and positron cross section and energy loss data for interactions with different media of increasing complexity: atoms, molecules, clusters and condense matter. Finally, we show how such a model can be used to develop an effective dosimetric tool at the molecular level (i.e. nanodosimetry). Recent experimental developments to study the fragmentation induced in biologically material by charge transfer from neutrals and negative ions are also included.
Original languageEnglish
Article number199
JournalEuropean Physical Journal D
Volume67
Issue number9
DOIs
Publication statusPublished - 25 Sep 2013

Keywords

  • MONTE-CARLO-SIMULATION
  • DIFFERENTIAL CROSS-SECTIONS
  • LIQUID WATER
  • SCREENING CORRECTIONS
  • POLYATOMIC-MOLECULES
  • IMAGINARY PART
  • STRAND BREAKS
  • SCATTERING
  • DNA
  • COLLISIONS

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