Modeling White-Matter Fiber-Orientation Uncertainty for Improved Probabilistic Tractography

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Tractography uses fiber-orientation estimates to trace the likely paths of white-matter tracts through the brain, in order to map brain connectivity non-invasively. In this paper, we propose a novel probabilistic framework for modeling fiber-orientation uncertainty and improve probabilistic tractography. The main innovation in the present formulation consists in coupling a particle filtering process with a clustered-mixture model approach to model directional data. Mixtures of von Mises-Fisher (vMF) distributions are used to support the probabilistic estimation of intravoxel fiber directions. The fitted parameters of the clustered vMF mixture at each voxel are then used to estimate white-matter pathways using particle filtering techniques. The technique is validated on simulated as well as on real human brain data experiments.
Original languageUnknown
Title of host publicationSCITEPRESS – Science and Technology Publications, INSTICC – Institute for Systems and Technologies of Information, Control and Communication
Publication statusPublished - 1 Jan 2014
EventNEUROTECHNIX 2014 – 2nd International Congress on Neurotechnology, Electronics and Informatics -
Duration: 1 Jan 2014 → …


ConferenceNEUROTECHNIX 2014 – 2nd International Congress on Neurotechnology, Electronics and Informatics
Period1/01/14 → …

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