Modeling protein complexes with BiGGER

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38 Citations (Scopus)

Abstract

This article describes the method and results of our participation in the Critical Assessment of PRediction of Interactions (CAPRI) experiment, using the protein docking program BiGGER (Bimolecular complex Generation with Global Evaluation and Ranking) (Palma et al., Proteins 2000;39: 372-384). Of five target complexes (CAPRI targets 2, 4, 5, 6, and 7), only one was successfully predicted (target 6), but BiGGER generated reasonable models for targets 4, 5, and 7, which could have been identified if additional biochemical information had been available.

Original languageEnglish
Pages (from-to)19-23
Number of pages5
JournalProteins: Structure, Function and Genetics
Volume52
Issue number1
DOIs
Publication statusPublished - 1 Jul 2003

Keywords

  • Complex prediction
  • Docking
  • Modeling
  • Protein interaction

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