TY - JOUR
T1 - Mo and W bis-MGD enzymes: nitrate reductases and formate dehydrogenases
AU - Moura, José J. G.
AU - Brondino, Carlos D.
AU - Trincão, José
AU - Romão, Maria João
N1 - C.D.B. and J.J.G.M. thank SECYT (Argentina) and GRICES (Portugal) for a bi-national grant. The work was supported by projects EC HPRN-CT-1999-00084, POCTI/1999/ BME/35078, and POCT/BME/36152/99.
PY - 2004/10/1
Y1 - 2004/10/1
N2 - Molybdenum and tungsten are second- and third-row transition elements, respectively, which are found in a mononuclear form in the active site of a diverse group of enzymes that generally catalyze oxygen atom transfer reactions. Mononuclear Mo-containing enzymes have been classified into three families: xanthine oxidase, DMSO reductase, and sulfite oxidase. The proteins of the DMSO reductase family present the widest diversity of properties among its members and our knowledge about this family was greatly broadened by the study of the enzymes nitrate reductase and formate dehydrogenase, obtained from different sources. We discuss in this review the information of the better characterized examples of these two types of Mo enzymes and W enzymes closely related to the members of the DMSO reductase family. We briefly summarize, also, the few cases reported so far for enzymes that can function either with Mo or W at their active site.
AB - Molybdenum and tungsten are second- and third-row transition elements, respectively, which are found in a mononuclear form in the active site of a diverse group of enzymes that generally catalyze oxygen atom transfer reactions. Mononuclear Mo-containing enzymes have been classified into three families: xanthine oxidase, DMSO reductase, and sulfite oxidase. The proteins of the DMSO reductase family present the widest diversity of properties among its members and our knowledge about this family was greatly broadened by the study of the enzymes nitrate reductase and formate dehydrogenase, obtained from different sources. We discuss in this review the information of the better characterized examples of these two types of Mo enzymes and W enzymes closely related to the members of the DMSO reductase family. We briefly summarize, also, the few cases reported so far for enzymes that can function either with Mo or W at their active site.
KW - DSMO reductase family
KW - Formate dehydrogenase
KW - Molybdenum-containing enzymes
KW - Nitrate reductase
KW - Tungsten-containing enzymes
UR - http://www.scopus.com/inward/record.url?scp=8644286154&partnerID=8YFLogxK
U2 - 10.1007/s00775-004-0573-9
DO - 10.1007/s00775-004-0573-9
M3 - Short survey
C2 - 15311335
AN - SCOPUS:8644286154
SN - 0949-8257
VL - 9
SP - 791
EP - 799
JO - JBIC Journal of Biological Inorganic Chemistry
JF - JBIC Journal of Biological Inorganic Chemistry
IS - 7
ER -