Mixed ligand aroylhydrazone and N-donor heterocyclic Lewis base Cu(II) complexes as potential antiproliferative agents

Manas Sutradhar, Rajeshwari, Tannistha Roy Barman, Alexandra R. Fernandes, Fabiana Paradinha, Catarina Roma-Rodrigues, M. Fátima C. Guedes da Silva, Armando J.L. Pombeiro

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A series of four mixed ligand aroylhydrazone and N-donor heterocyclic Lewis base Cu(II) complexes [CuL(X)]2 [L refers to the dianionic form of (5-bromo-2-hydroxybenzylidene)-2-hydroxybenzohydrazide; X = pyrazine (Pz; 1), pyridine (Py; 2), imidazole (Imz; 3) and 3-pyridinecarbonitrile (3-PyCN; 4)] has been synthesized and characterized by elemental analysis, various spectroscopic techniques and X-ray crystallography (for 1, 2 and 4). The antiproliferative effect of complexes 1–4 was examined in 4 human tumor cell lines (ovarian carcinoma (A2780), colorectal carcinoma (HCT116), lung adenocarcinoma (A549) and breast adenocarcinoma (MCF7)) and in normal human primary Fibroblasts. Complex 4 exhibits a high cytotoxic activity against ovarian and colorectal carcinoma cells (A2780, HCT116 respectively), with IC50 much lower than those for normal primary fibroblasts. Complex 4 could induce cell death via apoptosis but not autophagy in colorectal carcinoma cells.

Original languageEnglish
Pages (from-to)267-275
Number of pages9
JournalJournal of Inorganic Biochemistry
Volume175
DOIs
Publication statusPublished - 1 Oct 2017

Keywords

  • Antiproliferative agent
  • Aroylhydrazone ligand
  • Human tumor cell lines
  • Mixed ligand copper(II) complexes
  • X-ray structure

Fingerprint Dive into the research topics of 'Mixed ligand aroylhydrazone and N-donor heterocyclic Lewis base Cu(II) complexes as potential antiproliferative agents'. Together they form a unique fingerprint.

  • Cite this