Mixed ligand aroylhydrazone and N-donor heterocyclic Lewis base Cu(II) complexes as potential antiproliferative agents

Manas Sutradhar, Rajeshwari, Tannistha Roy Barman, Alexandra R. Fernandes, Fabiana Paradinha, Catarina Roma-Rodrigues, M. Fátima C. Guedes da Silva, Armando J.L. Pombeiro

Research output: Contribution to journalArticle

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Abstract

A series of four mixed ligand aroylhydrazone and N-donor heterocyclic Lewis base Cu(II) complexes [CuL(X)]2 [L refers to the dianionic form of (5-bromo-2-hydroxybenzylidene)-2-hydroxybenzohydrazide; X = pyrazine (Pz; 1), pyridine (Py; 2), imidazole (Imz; 3) and 3-pyridinecarbonitrile (3-PyCN; 4)] has been synthesized and characterized by elemental analysis, various spectroscopic techniques and X-ray crystallography (for 1, 2 and 4). The antiproliferative effect of complexes 1–4 was examined in 4 human tumor cell lines (ovarian carcinoma (A2780), colorectal carcinoma (HCT116), lung adenocarcinoma (A549) and breast adenocarcinoma (MCF7)) and in normal human primary Fibroblasts. Complex 4 exhibits a high cytotoxic activity against ovarian and colorectal carcinoma cells (A2780, HCT116 respectively), with IC50 much lower than those for normal primary fibroblasts. Complex 4 could induce cell death via apoptosis but not autophagy in colorectal carcinoma cells.

Original languageEnglish
Pages (from-to)267-275
Number of pages9
JournalJournal of Inorganic Biochemistry
Volume175
DOIs
Publication statusPublished - 1 Oct 2017

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Lewis Bases
Colorectal Neoplasms
Cells
Fibroblasts
Ligands
HCT116 Cells
Pyrazines
X ray crystallography
X Ray Crystallography
Autophagy
Cell death
Tumor Cell Line
Inhibitory Concentration 50
Tumors
Adenocarcinoma
Breast
Cell Death
Apoptosis
Carcinoma
Chemical analysis

Keywords

  • Antiproliferative agent
  • Aroylhydrazone ligand
  • Human tumor cell lines
  • Mixed ligand copper(II) complexes
  • X-ray structure

Cite this

Sutradhar, Manas ; Rajeshwari ; Roy Barman, Tannistha ; Fernandes, Alexandra R. ; Paradinha, Fabiana ; Roma-Rodrigues, Catarina ; Guedes da Silva, M. Fátima C. ; Pombeiro, Armando J.L. / Mixed ligand aroylhydrazone and N-donor heterocyclic Lewis base Cu(II) complexes as potential antiproliferative agents. In: Journal of Inorganic Biochemistry. 2017 ; Vol. 175. pp. 267-275.
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abstract = "A series of four mixed ligand aroylhydrazone and N-donor heterocyclic Lewis base Cu(II) complexes [CuL(X)]2 [L refers to the dianionic form of (5-bromo-2-hydroxybenzylidene)-2-hydroxybenzohydrazide; X = pyrazine (Pz; 1), pyridine (Py; 2), imidazole (Imz; 3) and 3-pyridinecarbonitrile (3-PyCN; 4)] has been synthesized and characterized by elemental analysis, various spectroscopic techniques and X-ray crystallography (for 1, 2 and 4). The antiproliferative effect of complexes 1–4 was examined in 4 human tumor cell lines (ovarian carcinoma (A2780), colorectal carcinoma (HCT116), lung adenocarcinoma (A549) and breast adenocarcinoma (MCF7)) and in normal human primary Fibroblasts. Complex 4 exhibits a high cytotoxic activity against ovarian and colorectal carcinoma cells (A2780, HCT116 respectively), with IC50 much lower than those for normal primary fibroblasts. Complex 4 could induce cell death via apoptosis but not autophagy in colorectal carcinoma cells.",
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Sutradhar, M, Rajeshwari, Roy Barman, T, Fernandes, AR, Paradinha, F, Roma-Rodrigues, C, Guedes da Silva, MFC & Pombeiro, AJL 2017, 'Mixed ligand aroylhydrazone and N-donor heterocyclic Lewis base Cu(II) complexes as potential antiproliferative agents', Journal of Inorganic Biochemistry, vol. 175, pp. 267-275. https://doi.org/10.1016/j.jinorgbio.2017.07.034

Mixed ligand aroylhydrazone and N-donor heterocyclic Lewis base Cu(II) complexes as potential antiproliferative agents. / Sutradhar, Manas; Rajeshwari; Roy Barman, Tannistha; Fernandes, Alexandra R.; Paradinha, Fabiana; Roma-Rodrigues, Catarina; Guedes da Silva, M. Fátima C.; Pombeiro, Armando J.L.

In: Journal of Inorganic Biochemistry, Vol. 175, 01.10.2017, p. 267-275.

Research output: Contribution to journalArticle

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AU - Sutradhar, Manas

AU - Rajeshwari, null

AU - Roy Barman, Tannistha

AU - Fernandes, Alexandra R.

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AU - Guedes da Silva, M. Fátima C.

AU - Pombeiro, Armando J.L.

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