Communication between vascular (endothelial) and blood (haematopoietic) cells in adult bone marrow (BM) is essential for maintaining normal haematopoiesis. Micro RNAs (miRNAs) are key regulators of gene expression, involved in the regulation of numerous cellular processes. miRNA signatures (profiles) of BM disorders may allow the prediction of disease prognosis and responses to treatments. In this article we suggest that miRNA profiling of BM endothelial cells may provide specific clues to aid in the understanding of normal and malignant BM function.
|Number of pages||3|
|Journal||Bio Tech International|
|Publication status||Published - 2010|