MicroRNAs and cancer drug resistance: over two thousand characters in search of a role

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Abstract

MicroRNAs (miRNAs), a group of small regulatory noncoding RNAs, transformed our thinking on gene regulation. More than two thousand human miRNAs have been identified thus far. These bind imperfectly to the 3’-untranslated region of target mRNA and have been involved in several pathological conditions including cancer. In fact, major hallmarks of cancer, such as the cell cycle, cell proliferation, survival and invasion are modulated by miRNAs. Cancer drug resistance (CDR) has also been described as being modulated by miRNAs. CDR remains a burden for cancer therapy and patients’ outcome, often resulting in more aggressive tumours that tend to metastasize to distant organs. In this review we discuss the role of miRNAs influencing drug metabolism and drug influx/efflux, two important mechanisms of CDR.
Original languageEnglish
Pages (from-to)618-633
JournalCancer Drug Resistance
Volume2
DOIs
Publication statusPublished - 16 Sep 2019

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MicroRNAs
Drug Resistance
Neoplasms
Small Untranslated RNA
3' Untranslated Regions
Pharmaceutical Preparations
Cell Survival
Cell Cycle
Cell Proliferation
Messenger RNA
Genes

Keywords

  • MicroRNAs
  • gene regulation
  • cancer drug resistance
  • drug transporters
  • drug metabolism

Cite this

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title = "MicroRNAs and cancer drug resistance: over two thousand characters in search of a role",
abstract = "MicroRNAs (miRNAs), a group of small regulatory noncoding RNAs, transformed our thinking on gene regulation. More than two thousand human miRNAs have been identified thus far. These bind imperfectly to the 3’-untranslated region of target mRNA and have been involved in several pathological conditions including cancer. In fact, major hallmarks of cancer, such as the cell cycle, cell proliferation, survival and invasion are modulated by miRNAs. Cancer drug resistance (CDR) has also been described as being modulated by miRNAs. CDR remains a burden for cancer therapy and patients’ outcome, often resulting in more aggressive tumours that tend to metastasize to distant organs. In this review we discuss the role of miRNAs influencing drug metabolism and drug influx/efflux, two important mechanisms of CDR.",
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author = "Gomes, {Bruno Costa} and Jos{\'e} Rueff and Rodrigues, {Ant{\'o}nio Sebasti{\~a}o}",
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AU - Rodrigues, António Sebastião

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AB - MicroRNAs (miRNAs), a group of small regulatory noncoding RNAs, transformed our thinking on gene regulation. More than two thousand human miRNAs have been identified thus far. These bind imperfectly to the 3’-untranslated region of target mRNA and have been involved in several pathological conditions including cancer. In fact, major hallmarks of cancer, such as the cell cycle, cell proliferation, survival and invasion are modulated by miRNAs. Cancer drug resistance (CDR) has also been described as being modulated by miRNAs. CDR remains a burden for cancer therapy and patients’ outcome, often resulting in more aggressive tumours that tend to metastasize to distant organs. In this review we discuss the role of miRNAs influencing drug metabolism and drug influx/efflux, two important mechanisms of CDR.

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KW - drug transporters

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