Abstract
The discovery of small regulatory noncoding RNAs revolutionized our thinking on gene regulation. The class of microRNAs (miRs), a group of small noncoding RNAs (20-22 nt in length) that bind imperfectly to the 3'-untranslated region of target mRNA, has been insistently implicated in several pathological conditions including cancer. Indeed, major hallmarks of cancer, such as cell differentiation, cell proliferation, cell cycle, cell survival, and cell invasion, has been described as being regulated by miRs. Recent studies have also implicated miRs in cancer drug resistance. Regardless of the several studies done until now, drug resistance still is a burden for cancer therapy and patients' outcome, often resulting in more aggressive tumors that tend to metastasize to distant organs. Hence, with this review, we aim to summarize the miRs that influence molecular pathways that are involved in cancer drug resistance, such as drug metabolism, drug influx/efflux, DNA damage response (DDR), epithelial-to-mesenchymal transition (EMT), and cancer stem cells.
| Original language | English |
|---|---|
| Pages (from-to) | 137-62 |
| Number of pages | 26 |
| Journal | Methods In Molecular Biology (Clifton, N.J.) |
| Volume | 1395 |
| DOIs | |
| Publication status | Published - 2016 |
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Keywords
- MicroRNA
- Drug resistance
- Noncoding RNAs
- Cancer
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MicroRNAs and Cancer Drug Resistance. / Gomes, Bruno Costa ; Rueff, José; Rodrigues, A.S.
In: Methods In Molecular Biology (Clifton, N.J.), Vol. 1395, 2016, p. 137-62.Research output: Contribution to journal › Article
TY - JOUR
T1 - MicroRNAs and Cancer Drug Resistance
AU - Gomes, Bruno Costa
AU - Rueff, José
AU - Rodrigues, A.S.
N1 - PMID:26910073
PY - 2016
Y1 - 2016
N2 - The discovery of small regulatory noncoding RNAs revolutionized our thinking on gene regulation. The class of microRNAs (miRs), a group of small noncoding RNAs (20-22 nt in length) that bind imperfectly to the 3'-untranslated region of target mRNA, has been insistently implicated in several pathological conditions including cancer. Indeed, major hallmarks of cancer, such as cell differentiation, cell proliferation, cell cycle, cell survival, and cell invasion, has been described as being regulated by miRs. Recent studies have also implicated miRs in cancer drug resistance. Regardless of the several studies done until now, drug resistance still is a burden for cancer therapy and patients' outcome, often resulting in more aggressive tumors that tend to metastasize to distant organs. Hence, with this review, we aim to summarize the miRs that influence molecular pathways that are involved in cancer drug resistance, such as drug metabolism, drug influx/efflux, DNA damage response (DDR), epithelial-to-mesenchymal transition (EMT), and cancer stem cells.
AB - The discovery of small regulatory noncoding RNAs revolutionized our thinking on gene regulation. The class of microRNAs (miRs), a group of small noncoding RNAs (20-22 nt in length) that bind imperfectly to the 3'-untranslated region of target mRNA, has been insistently implicated in several pathological conditions including cancer. Indeed, major hallmarks of cancer, such as cell differentiation, cell proliferation, cell cycle, cell survival, and cell invasion, has been described as being regulated by miRs. Recent studies have also implicated miRs in cancer drug resistance. Regardless of the several studies done until now, drug resistance still is a burden for cancer therapy and patients' outcome, often resulting in more aggressive tumors that tend to metastasize to distant organs. Hence, with this review, we aim to summarize the miRs that influence molecular pathways that are involved in cancer drug resistance, such as drug metabolism, drug influx/efflux, DNA damage response (DDR), epithelial-to-mesenchymal transition (EMT), and cancer stem cells.
KW - MicroRNA
KW - Drug resistance
KW - Noncoding RNAs
KW - Cancer
U2 - 10.1007/978-1-4939-3347-1_9
DO - 10.1007/978-1-4939-3347-1_9
M3 - Article
VL - 1395
SP - 137
EP - 162
JO - Methods In Molecular Biology (Clifton, N.J.)
JF - Methods In Molecular Biology (Clifton, N.J.)
SN - 1064-3745
ER -