Microbial hosts as a promising platform for polyphenol production

Adelaide Braga, Isabel Rocha, Nuno Faria

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Citations (Scopus)


Plants synthesize a variety of different secondary metabolites, such as polyphenols, terpenoids, alkaloids, etc., with pharmaceutical and nutraceutical importance. Polyphenols have shown numerous health benefits with rare side effects. However, the extraction of these compounds from natural sources cannot meet the increasing consumer demand for natural products, and its purification is often difficult, making the overall process too expensive. In contrast, microbial pro duction of polyphenols is a powerful alternative to produce natural products in large amounts, in an environmentally sustainable way. Nevertheless, plant-derived polyphenols are not naturally produced by microorganisms and therefore require the integration of the heterologous pathway from plants through genetic engineering techniques. In the present chapter, the recent advances in microbial production of plant-derived polyphenols, emphasizing on flavonoids, anthocyanins, curcuminoids, and stilbenes, have been summarized. In addition, different strategies used to increase the product yield, and the production processes are also highlighted.

Original languageEnglish
Title of host publicationNatural Bio-active Compounds
Subtitle of host publicationVolume 1: Production and Applications
PublisherSpringer Singapore
Number of pages33
ISBN (Electronic)9789811371547
ISBN (Print)9789811371530
Publication statusPublished - 1 Jan 2019


  • Anthocyanin
  • Curcuminoids
  • Flavonoids
  • Microorganisms
  • Stilbenes


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