In the current globalized and competitive business world it has become increasingly more important that companies adapt their knowledge bases, in order to establish more dynamic business partnerships. However, one of the main problems found in the establishment of such partnerships has to do with the lack of interoperability between technologic systems, especially those related to the semantic of shared knowledge. The integration and sharing of the knowledge representation elements of companies, performs a key role in the research challenges in the business interoperability area. The paper presents a methodology to analyse the economic viability of companies in the needed effort to the conception of a common knowledge base in their operational domain area, in order to stimulate interoperability in the business cooperation. These studies also have as objective to support the development of the thesis that argues that in the future, the capability to adapt the semantics of business information systems will promote collaboration between companies, providing them new business opportunities.