Metastatic organotropism: a brief overview

Margarida Carrolo; João A.I. Miranda; Guilherme Vilhais; António Quintela; Mário Fontes e. Sousa; Diogo Alpuim Costa; Francisco R. Pinto

doi:10.3389/fonc.2024.1358786

Metastatic organotropism: a brief overview

Margarida Carrolo, João A.I. Miranda, Guilherme Vilhais, António Quintela, Mário Fontes e. Sousa, Diogo Alpuim Costa, Francisco R. Pinto

NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Research output: Contribution to journal › Short survey › peer-review

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Abstract

Organotropism has been known since 1889, yet this vital component of metastasis has predominantly stayed elusive. This mini-review gives an overview of the current understanding of the underlying mechanisms of organotropism and metastases development by focusing on the formation of the pre-metastatic niche, immune defenses against metastases, and genomic alterations associated with organotropism. The particular case of brain metastases is also addressed, as well as the impact of organotropism in cancer therapy. The limited comprehension of the factors behind organotropism underscores the necessity for efficient strategies and treatments to manage metastases.

Original language	English
Article number	1358786
Journal	Frontiers in Oncology
Volume	14
DOIs	https://doi.org/10.3389/fonc.2024.1358786
Publication status	Published - 2024

Keywords

brain metastasis
immune response to metastasis
metastasis
organotropism
pre-metastatic niche

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fonc.2024.1358786

fonc-14-1358786Final published version, 720 KBLicence: CC BY

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title = "Metastatic organotropism: a brief overview",

abstract = "Organotropism has been known since 1889, yet this vital component of metastasis has predominantly stayed elusive. This mini-review gives an overview of the current understanding of the underlying mechanisms of organotropism and metastases development by focusing on the formation of the pre-metastatic niche, immune defenses against metastases, and genomic alterations associated with organotropism. The particular case of brain metastases is also addressed, as well as the impact of organotropism in cancer therapy. The limited comprehension of the factors behind organotropism underscores the necessity for efficient strategies and treatments to manage metastases.",

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year = "2024",

doi = "10.3389/fonc.2024.1358786",

language = "English",

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journal = "Frontiers in Oncology",

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TY - JOUR

T1 - Metastatic organotropism

T2 - a brief overview

AU - Carrolo, Margarida

AU - Miranda, João A.I.

AU - Vilhais, Guilherme

AU - Quintela, António

AU - Sousa, Mário Fontes e.

AU - Costa, Diogo Alpuim

AU - Pinto, Francisco R.

PY - 2024

Y1 - 2024

N2 - Organotropism has been known since 1889, yet this vital component of metastasis has predominantly stayed elusive. This mini-review gives an overview of the current understanding of the underlying mechanisms of organotropism and metastases development by focusing on the formation of the pre-metastatic niche, immune defenses against metastases, and genomic alterations associated with organotropism. The particular case of brain metastases is also addressed, as well as the impact of organotropism in cancer therapy. The limited comprehension of the factors behind organotropism underscores the necessity for efficient strategies and treatments to manage metastases.

AB - Organotropism has been known since 1889, yet this vital component of metastasis has predominantly stayed elusive. This mini-review gives an overview of the current understanding of the underlying mechanisms of organotropism and metastases development by focusing on the formation of the pre-metastatic niche, immune defenses against metastases, and genomic alterations associated with organotropism. The particular case of brain metastases is also addressed, as well as the impact of organotropism in cancer therapy. The limited comprehension of the factors behind organotropism underscores the necessity for efficient strategies and treatments to manage metastases.

KW - brain metastasis

KW - immune response to metastasis

KW - metastasis

KW - organotropism

KW - pre-metastatic niche

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DO - 10.3389/fonc.2024.1358786

M3 - Short survey

AN - SCOPUS:85193014411

SN - 2234-943X

VL - 14

JO - Frontiers in Oncology

JF - Frontiers in Oncology

M1 - 1358786

ER -

Metastatic organotropism: a brief overview

Abstract

Keywords

UN SDGs

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