Metal centers in biomolecular solid-state NMR

José Malanho Silva, Linda Cerofolini, Stefano Giuntini, Vito Calderone, Carlos F. G. C. Geraldes, Anjos L. Macedo, Giacomo Parigi, Marco Fragai, Enrico Ravera, Claudio Luchinat

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Solid state NMR (SSNMR) has earned a substantial success in the characterization of paramagnetic systems over the last decades. Nowadays, the resolution and sensitivity of solid state NMR in biological molecules has improved significantly and these advancements can be translated into the study of paramagnetic biomolecules. However, the electronic properties of different metal centers affect the quality of their SSNMR spectra differently, and not all systems turn out to be equally easy to approach by this technique. In this review we will try to give an overview of the properties of different paramagnetic centers and how they can be used to increase the chances of experimental success.

Original languageEnglish
Pages (from-to)99-109
JournalJournal Of Structural Biology
Volume206
Issue number1
DOIs
Publication statusPublished - 1 Apr 2019

Keywords

  • Biosolids
  • Electronic structure
  • Paramagnetic NMR
  • Resolution
  • Sensitivity

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