Metal-Catalyzed Cross-Coupling Reactions of Aminopyridines

The aminopyridines are key building blocks in the synthesis of bioactive heterocyclic compounds such as azaindoles and imidazopyridines. The role of metal-catalyzed methods in aminopyridine functionalization, in particular the catalytic systems used, reaction conditions and the influence of aminopyridine substituents on the reaction outcome, is outlined. The review covers different metal-catalyzed reactions developed for C-C and C-N bond formation. One-pot and multicomponent reactions directed towards aminopyridine-based heterocyclic compounds are also covered. Besides cross-coupling reactions, other reactions involving metal catalysts, such as C-H activation and oxidative cyclization, are also reported. The idea is to give the reader an overview of the challenges and limitations of the use of metal-catalyzed synthesis for aminopyridine functionalization in order to make a contribution to chemists working in organic synthesis field.