Metal-Catalyzed Cross-Coupling Reactions of Aminopyridines

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24 Citations (Scopus)

Abstract

The aminopyridines are key building blocks in the synthesis of bioactive heterocyclic compounds such as azaindoles and imidazopyridines. The role of metal-catalyzed methods in aminopyridine functionalization, in particular the catalytic systems used, reaction conditions and the influence of aminopyridine substituents on the reaction outcome, is outlined. The review covers different metal-catalyzed reactions developed for C-C and C-N bond formation. One-pot and multicomponent reactions directed towards aminopyridine-based heterocyclic compounds are also covered. Besides cross-coupling reactions, other reactions involving metal catalysts, such as C-H activation and oxidative cyclization, are also reported. The idea is to give the reader an overview of the challenges and limitations of the use of metal-catalyzed synthesis for aminopyridine functionalization in order to make a contribution to chemists working in organic synthesis field.

Original languageEnglish
Pages (from-to)7197-7234
Number of pages38
JournalEuropean Journal of Organic Chemistry
Volume2015
Issue number33
DOIs
Publication statusPublished - 1 Nov 2015

Keywords

  • C-C coupling
  • C-N coupling
  • Cross-coupling
  • Nitrogen heterocycles
  • Synthetic methods

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