Metabolic cooperation between cancer and non-cancerous stromal cells is pivotal in cancer progression

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Abstract

The way cancer cells adapt to microenvironment is crucial for the success of carcinogenesis, and metabolic fitness is essential for a cancer cell to survive and proliferate in a certain organ/tissue. The metabolic remodeling in a tumor niche is endured not only by cancer cells but also by non-cancerous cells that share the same microenvironment. For this reason, tumor cells and stromal cells constitute a complex network of signal and organic compound transfer that supports cellular viability and proliferation. The intensive dual-address cooperation of all components of a tumor sustains disease progression and metastasis. Herein, we will detail the role of cancer-associated fibroblasts, cancer-associated adipocytes, and inflammatory cells, mainly monocytes/macrophages (tumor-associated macrophages), in the remodeling and metabolic adaptation of tumors.

Original languageEnglish
Article number1010428318756203
JournalTumor Biology
Volume40
Issue number2
DOIs
Publication statusPublished - Feb 2018

Keywords

  • Cancer metabolism
  • cancer-associated adipocytes
  • cancer-associated fibroblasts
  • microenvironment
  • tumor-associated macrophages

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