TY - JOUR
T1 - Metabolic cooperation between cancer and non-cancerous stromal cells is pivotal in cancer progression
AU - Lopes-Coelho, Filipa
AU - Gouveia-Fernandes, Sofia
AU - Serpa, Jacinta
N1 - Funding The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported through iNOVA4Health— UID/Multi/04462/2013, a program financially supported by Fundação para a Ciência e Tecnologia (FCT; PhD ProRegeM program, PD/BD/128337/2017)/Ministério da Educação e Ciência through national funds and co-funded by FEDER under the PT2020 Partnership Agreement.
PY - 2018/2
Y1 - 2018/2
N2 - The way cancer cells adapt to microenvironment is crucial for the success of carcinogenesis, and metabolic fitness is essential for a cancer cell to survive and proliferate in a certain organ/tissue. The metabolic remodeling in a tumor niche is endured not only by cancer cells but also by non-cancerous cells that share the same microenvironment. For this reason, tumor cells and stromal cells constitute a complex network of signal and organic compound transfer that supports cellular viability and proliferation. The intensive dual-address cooperation of all components of a tumor sustains disease progression and metastasis. Herein, we will detail the role of cancer-associated fibroblasts, cancer-associated adipocytes, and inflammatory cells, mainly monocytes/macrophages (tumor-associated macrophages), in the remodeling and metabolic adaptation of tumors.
AB - The way cancer cells adapt to microenvironment is crucial for the success of carcinogenesis, and metabolic fitness is essential for a cancer cell to survive and proliferate in a certain organ/tissue. The metabolic remodeling in a tumor niche is endured not only by cancer cells but also by non-cancerous cells that share the same microenvironment. For this reason, tumor cells and stromal cells constitute a complex network of signal and organic compound transfer that supports cellular viability and proliferation. The intensive dual-address cooperation of all components of a tumor sustains disease progression and metastasis. Herein, we will detail the role of cancer-associated fibroblasts, cancer-associated adipocytes, and inflammatory cells, mainly monocytes/macrophages (tumor-associated macrophages), in the remodeling and metabolic adaptation of tumors.
KW - Cancer metabolism
KW - cancer-associated adipocytes
KW - cancer-associated fibroblasts
KW - microenvironment
KW - tumor-associated macrophages
U2 - 10.1177/1010428318756203
DO - 10.1177/1010428318756203
M3 - Review article
C2 - 29421992
SN - 1010-4283
VL - 40
JO - Tumor Biology
JF - Tumor Biology
IS - 2
M1 - 1010428318756203
ER -
